5.06417

SB 242084 Hydrochloride

• 동의어(들): SB 242084 Hydrochloride, 5-HT _2C receptor antagonist, SB 242084 Hydrochloride, SB-242084 Hydrochloride, SB242084 Hydrochloride
• 실험식(Hill 표기법): C₂₁H₁₉ClN₄O₂ · xHCl
• CAS Number: 1260505-34-7
• Molecular Weight: 394.85 (free base basis)
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• Quality Level: 100
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: off-white to pale yellow; pale yellow
• solubility: water: soluble
• 저장 온도: −20°C
• InChI: 1S/C21H19ClN4O2.2ClH/c1-13-10-15-7-9-26(18(15)11-17(13)22)21(27)25-16-5-6-20(24-12-16)28-19-4-3-8-23-14(19)2;;/h3-6,8,10-12H,7,9H2,1-2H3,(H,25,27);2*1H
• InChI key: GCMNSEILNIPNSX-UHFFFAOYSA-N

설명

일반 설명

A selective, brain-penetrant 5-HT_2C receptor antagonist (pKi 8.2-9.0 ), with some effects on the 5-HT_2B receptor (pKi 6.8-7.0) and 5-HT_2A receptor (pKi 6.1-6.8). SB 242084 has been shown to increase the effectiveness of the selective serotonin reuptake inhibitor (SSRI) class of antidepressants, and may also reduce their side effects. In animal studies, SB-242,084 produced stimulant-type activity and reinforcing effects, somewhat similar to but much weaker than cocaine or amphetamines. In vivo (ocular) IC₅₀ values reported at 2.08 µM.

생화학적/생리학적 작용

Primary Target
5-HT_2C

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Manvich, D. F., et al. 2012. J Pharmacol. Exp. Ther.342, 761.
Burghardt, N. S., et al. 2007. Biol Psychiatry62, 1111.

Sharif, N. A., et al. 2007. J. Ocul. Pharmacol. Ther.23, 1.

Knight A. R., et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.
Kennett G.A., et al. 1997. Neuropharmacol. 36, 609.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable