506274

PACOCF₃

A novel Ca²⁺-independent and reversible inhibitor of phospholipase A₂ (PLA₂; IC₅₀ = 3.8 µM).

• 동의어(들): PACOCF₃, Palmitoyl Trifluoromethyl Ketone
• 실험식(Hill 표기법): C₁₇H₃₁F₃O
• CAS Number: 141022-99-3
• Molecular Weight: 308.42
• MDL number: MFCD00797669
• UNSPSC 코드: 12352211
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (TLC)
• 양식: liquid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 배송 상태: wet ice
• 저장 온도: −20°C
• SMILES string: FC(F)(F)C(=O)CCCCCCCCCCCCCCC
• InChI: 1S/C17H31F3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(21)17(18,19)20/h2-15H2,1H3
• InChI key: MAHYXYTYTLCTQD-UHFFFAOYSA-N

설명

일반 설명

A novel Ca²⁺-independent and reversible inhibitor of phospholipase A₂ (PLA₂; IC₅₀ = 3.8 µM). May also inhibit Ca²⁺-dependent PLA₂ at much higher concentrations (IC₅₀ = 45 µM).

A novel Ca²⁺-independent phospholipase A₂ inhibitor (IC₅₀ = 3.8 µM). May also inhibit Ca²⁺-dependent phospholipase A₂ at higher concentrations (IC₅₀ = 45 µM)

생화학적/생리학적 작용

Cell permeable: no

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 3.8 µM and 45 µM against phospholipase A2 (PLA2) and Ca2+-dependent PLA2, respectively.

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution in DMSO, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Product has a very low melting point. The product will change from a solid to a liquid if held in your hand or kept at room temperature or warmer for any period of time. It is best to keep the product cool while in use by placing it in the refrigerator or on ice during experimentation. Once diluted in buffer, do not store in aqueous solutions for >1 day.

Supplied as a solution in ethanol. To change the solvent, evaporate the ethanol with a stream of nitrogen and immediately reconstitute with the solvent of choice. Soluble in DMSO (30 mg/ml). Only minimally soluble in aqueous buffers; do not use basic buffers; unstable at basic pH.

기타 정보

Conde-Frieboes, K., et al. 1996. J. Am. Chem. Soc. 118, 5519.
Lio, Y.C., et al. 1996. Biochim. Biophys. Acta 1302, 55.
Ackermann, E.J., et al. 1995. J. Biol. Chem.270, 445.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3