5.06272

SB 206553 Hydrochloride

• 동의어(들): SB 206553 Hydrochloride, 5-HT _2C Serotonin Receptor Antagonist, SB 206553, 5-HT _2B Serotonin Receptor Antagonist, SB 206553, SB206553, SB-206553
• 실험식(Hill 표기법): C₁₇H₁₆N₄O · xHCl
• CAS Number: 158942-04-2
• Molecular Weight: 292.34 (free base basis)
• MDL number: MFCD00928314
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥99% (HPLC)
• Quality Level: 100
• 양식: solid
• 효능: 3.2 nM K_i
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: yellow
• solubility: DMSO: soluble
• 저장 온도: 2-8°C
• SMILES string: [n]1(c2c(cc3c(c2)CCN3C(=O)Nc4cnccc4)cc1)C
• InChI: 1S/C17H16N4O/c1-20-7-4-12-10-16-13(9-15(12)20)5-8-21(16)17(22)19-14-3-2-6-18-11-14/h2-4,6-7,9-11H,5,8H2,1H3,(H,19,22)
• InChI key: QJQORSLQNXDVGE-UHFFFAOYSA-N

설명

일반 설명

A selective 5-HT_2C serotonin receptor inhibitor with lesser affinity for 5-HT_2BR. Often used in conjunction with ketanserin to distinguish 5-HT_2AR and 5-HT_2CR activity. SB206553 has highest affinity for 5-HT_2CR (K_i = 3.2nM) and less for 5-HT_2BR (K_i = 5.5 nM) and 5-HT_2AR (K_i = 2,300 nM).

생화학적/생리학적 작용

Primary Target
5-HT_2C

Secondary Target
5-HT_2B

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Ros, R. et al. 2013. PNAS.110, 348.

Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.
Cussac, D. et al. 2002. Naunyn Schmiedebergs Arch. Pharmacol.365, 242.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable