5.05026

DNQX Disodium Salt

• 동의어(들): DNQX Disodium Salt, AMPA Glutamate Receptor Antagonist, DNQX, Kainate Glutamate Receptor Antagonist, DNQX
• 실험식(Hill 표기법): C₈H₂N₄Na₂O₆
• CAS Number: 2379-57-9
• Molecular Weight: 296.10
• MDL number: MFCD00069257
• UNSPSC 코드: 12352200

속성

• 분석: ≥99% (HPLC)
• Quality Level: 100
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: dark brown
• solubility: H₂O: 100 mM
• 저장 온도: 2-8°C
• InChI: 1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)
• InChI key: RWVIMCIPOAXUDG-UHFFFAOYSA-N

설명

일반 설명

A potent competitive antagonist selective for AMPA/kainate glutamate receptors (IC₅₀ = 0.19-1.66 µM and 0.35 µM for AMPA and GluK2 receptors, respectively). Routinely used as a tool to distinguish the role of neurotransmissions mediated by AMPA/kainate and NMDA receptors in studying brain functions and disorders.

생화학적/생리학적 작용

Primary Target
AMPA

Secondary Target
GluK2

Target IC₅₀: 0.19 to 1.66 uM

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Lee, S., et al. 2010. J. Neurophysiol.103, 1728.
Honor, T., et al. 1998. Science.241, 701.
Watkins, J., et al. 1990. Adv. Exp. Med. Biol.268, 49.
Davies, S., et al. 1990. Int. Rev. Neurobiol.32, 28.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable