5.04042

Doxorubicin Hydrochloride

InSolution, ≥98%

• 동의어(들): InSolution Doxorubicin, Hydrochloride, Adriamycin, HCl, 14-Hydroxydaunomycin, HCl
• 실험식(Hill 표기법): C₂₇H₂₉NO₁₁ · xHCl
• CAS Number: 25316-40-9
• Molecular Weight: 543.52 (free base basis)
• MDL number: MFCD00077757
• UNSPSC 코드: 12352101

속성

• Quality Level: 200
• 분석: ≥98% (HPLC)
• 양식: liquid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; avoid repeated freeze/thaw cycles; protect from light
• 저장 온도: −70°C
• InChI: 1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10?,13?,15-,17?,22?,27-;/m0./s1
• InChI key: MWWSFMDVAYGXBV-FGBJBKNOSA-N

설명

일반 설명

A 10 mM (5 mg/862 µL) sterile-filtered solution of Doxorubicin, HCl in H₂O.

An anti-tumor antibiotic and a highly effective myotoxin that inhibits topoisomerase II (IC₅₀ = 100 nM). Binds to nucleic acids, presumably by specific intercalation into the DNA double helix, inhibiting nucleic acid synthesis. Cytotoxicity seems to be due to its ability to intercalate with DNA, interact with plasma membranes, and take part in oxidation-reduction reactions. Induces apoptosis in rhabdomyosarcoma cell lines.

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

물리적 형태

A 10 mM (5 mg/862 µL) sterile-filtered solution of Doxorubicin, HCl (Cat. No. 324380) in H₂O.

재구성

Following initial thaw, aliquot and freeze (-20°C or -70°C). Aliquots are stable for up to 3 months at -20°C or for up to 6 months at -70°C.

기타 정보

A′Hern, R.P., and Gore, M.E. 1995.J. Clin. Oncol.13, 726.
Nooter, K., et al. 1995. Br. J. Cancer71, 556.
Noviello, E., et al. 1994. Mutat. Res.. 311, 21.
Anderson, R.D., et al. 1993. Mutat. Res.294, 215.
Hershko, C., et al. 1993. J. Lab. Clin. Med.122, 245.
Jongmans, W., et al. 1993. Mutat. Res.294, 207.
O′Shaughnessy, J.A., and Cowan, K.H. 1993. J. Am. Med. Assoc.270, 2089.
Theyer, G., et al. 1993. J. Urol.150, 1544.
Tritton, T.R., and Yee, G. 1982. Science217, 248.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany