499610

(5Z)-7-Oxozeaenol, Curvularia sp.

(5Z)-7-Oxozeaenol, CAS 66018-38-0, is a cell-permeable, highly potent, selective, irreversible, and ATP-competitive inhibitor of MAPKKK TAK1 activity (IC₅₀ = 8 nM).

• 동의어(들): (5Z)-7-Oxozeaenol, Curvularia sp., TAK1 Inhibitor
• 실험식(Hill 표기법): C₁₉H₂₂O₇
• CAS Number: 66018-38-0
• Molecular Weight: 362.37
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• solubility: DMSO: 10 mg/mL; ethanol: 5 mg/mL
• 배송 상태: wet ice
• 저장 온도: −20°C
• InChI: 1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3-4,6-7,9-11,15,18,21-23H,5,8H2,1-2H3
• InChI key: NEQZWEXWOFPKOT-UHFFFAOYSA-N

설명

일반 설명

A naturally isolated cell-permeable fungal resorcylic lactone that acts as a selective and highly potent inhibitor against the MAPKKK TAK1 activity (IC₅₀ = 8 nM) in an ATP-competitive and irreversible manner, while inhibiting MEK1 (IC₅₀ = 411 nM) and three other MAPKKKs (IC₅₀ ≥268 nM against MEKK1, ASK1, and MEKK4) only at much higher concentrations. Shown to inhibit IL-1-induced/TAK1-mediated, but not H₂O₂-induced/TAK1-independent, JNK and p38 phosphorylation in 293 cells. (5Z)-Zeaenol, Curvularia sp. (Cat. No. 499609) may serve as a negative control.

A naturally isolated cell-permeable fungal resorcylic lactone that acts as a selective and highly potent inhibitor against the MAPKKK TAK1 activity (IC₅₀ = 8 nM) in an ATP-competitive and irreversible manner, while inhibiting MEK1 (IC₅₀ = 411 nM) and three other MAPKKKs (IC₅₀ ≥268 nM against MEKK1, ASK1, and MEKK4) only at much higher concentrations. Shown to inhibit IL-1-induced/TAK1-mediated, but not H₂O₂-induced/TAK1-independent, JNK and p38 phosphorylation in 293 cells. (5Z)-Zeaenol, Curvularia sp.(Cat. No. 499609) may serve as a negative control.

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

기타 정보

Windheim, M., et al. 2007. Biochem. J.404, 179.
Choo, M.K., et al. 2006. Mol. Cancer Ther.5, 2970.
Safwat, N., et al. 2005. Endocrinology146, 4814.
Ninomiya-Tsuji, J., et al. 2003. J. Biol. Chem.278, 18485.
Rawlins, P., et al. 1999. Int. J. Immunopharmacol.21, 799.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable