492030

NS 2028

Potent, specific, and irreversible inhibitor of soluble guanylyl cyclase.

• 동의어(들): NS 2028, 4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one
• 실험식(Hill 표기법): C₉H₅BrN₂O₃
• CAS Number: 204326-43-2
• Molecular Weight: 269.05
• MDL number: MFCD01530052
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (NMR)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated
• 색상: white to off-white
• solubility: chloroform: 1 mg/mL; DMSO: 5 mg/mL; ethanol: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/C9H5BrN2O3/c10-5-1-2-7-6(3-5)12-8(4-14-7)11-15-9(12)13/h1-3H,4H2
• InChI key: MUDRLQRJCGJJTB-UHFFFAOYSA-N

설명

일반 설명

Potent, specific, and irreversible inhibitor of soluble guanylyl cyclase (IC₅₀ = 30 nM for basal and 200 nM for NO-stimulated enzyme activity; IC₅₀ = 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum).

생화학적/생리학적 작용

Cell permeable: no

Primary Target
basal soluble guanylyl cyclase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 30 nM for basal and 200 nM for NO-stimulated enzyme activity; 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C) for long-term storage. DMSO stock solutions are stable for up to 1 month at -20°C and for ~8 h at 4°C. Avoid freeze/thaw cycles of solutions.

기타 정보

Fleming, I., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 1123.
Olesen, S.P., et al. 1998. Br. J. Pharmacol. 123, 299.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable