475864

MK-2 Inhibitor III

The MK-2 Inhibitor III, also referenced under CAS 1186648-22-5, controls the biological activity of MK-2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 동의어(들): MK-2 Inhibitor III, 2-(2-Quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo-[3,2-c]pyridin-4-one
• 실험식(Hill 표기법): C₂₁H₁₆N₄O · xH₂O
• CAS Number: 1186648-22-5
• Molecular Weight: 340.38 (anhydrous basis)
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: pale yellow
• solubility: DMSO: 50 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C

설명

일반 설명

A cell-permeable pyrrolopyridinyl compound that acts as a potent, selective, and ATP-biniding site-targeting MK-2/MAPKAP-K2 inhibitor (IC₅₀ = 8.5, 81, and 210 nM agaisnt MK-2, MK-5, and MK-3, respectively), while exhibiting much less or no activity against 8 other commonly studied kinases. Shown to suppress LPS-induced TNF-α production in U937 cells (IC₅₀ = 4.4 µM).

A cell-permeable pyrrolopyridinyl compound that acts as an ATP-competitive inhibitor of MK-2/MAPKAP-K2 (IC₅₀ = 8.5, 81, and 210 nM against MK-2, MK-5, and MK-3, respectively), while exhibiting much less or no activity against 8 other commonly studied kinases. Shown to suppress LPS-induced TNF-α production in U937 cells (IC₅₀ = 4.4 µM).

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

기타 정보

Anderson, D.R., et al. 2007. J. Med. Chem.50, 2647.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable