475837

ISO-1

≥98% (HPLC), solid, MIF antagonist, Calbiochem^®

• 동의어(들): MIF Antagonist, ISO-1, (S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester, Macrophage Migration Inhibitory Factor Antagonist, ISO-1
• 실험식(Hill 표기법): C₁₂H₁₃NO₄
• CAS Number: 478336-92-4
• Molecular Weight: 235.24
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 제품명: MIF Antagonist, ISO-1, The MIF Antagonist, ISO-1, also referenced under CAS 478336-92-4, controls the biological activity of MIF.
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: light yellow
• solubility: DMSO: 10 mg/mL
• 배송 상태: wet ice
• 저장 온도: −20°C
• InChI: 1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3
• InChI key: AIXMJTYHQHQJLU-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable isoxazoline compound that displays anti-inflammatory properties. Inhibits MIF dopachrome tautomerase activity by binding to its catalytic active site (IC₅₀ = 7 µM for D-dopachrome tautomerase) and suppresses the production of TNFα, PGE₂ and COX-2 in human monocytes and arachidonic acid in RAW 264.7 macrophages. Shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic mouse model.

A cell-permeable isoxazoline compound that displays anti-inflammatory properties. Inhibits MIF tautomerase activity by binding to its catalytic active site (IC₅₀ = 7 µM for D-dopachrome tautomerase) and suppresses the production of TNFα, PGE₂ and COX-2 in human monocytes, and arachidonic acid in RAW 264.7 macrophages. Shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic mouse model. Also available as a 50 mM solution in DMSO (Cat. No. 505225).

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
MIF tautomerize

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 7 µM for D-dopachrome tautomerase

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable