412400

IQ-1

A cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/β-catenin signaling by targeting the PR72/130 subunit of PP2A and thereby blocking PP2A/Nkd complex formation.

• 동의어(들): IQ-1, 2-(4-Acetylphenylazo)-2-(3,3-dimethyl-3,4-dihydro-2H-isoquinolin-1-ylidene)-acetamide, Wnt Pathway Activator III
• 실험식(Hill 표기법): C₂₁H₂₂N₄O₂
• CAS Number: 331001-62-8
• Molecular Weight: 362.42
• MDL number: MFCD00354369
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: orange
• solubility: DMSO: 50 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: N1C(Cc2c(cccc2)C1=C(N=Nc3ccc(cc3)C(=O)C)C(=O)N)(C)C

설명

일반 설명

A cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/β-catenin signaling by targeting the PR72/130 subunit of PP2A and thereby blocking PP2A/Nkd complex formation, resulting in diminished β-catenin/p300 interaction and a concomitant increase in β-catenin/CBP usage. Co-adminitration of IQ-1 (4 µg/ml) and Wnt3a (100 ng/ml), but neither reagent alone, has been shown to be sufficient in maintaining long-term (>48 days) murine ESCs (Embryonic Stem Cells) pluripotency in the absence of serum.

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

기타 정보

Miyabayashi, T., et al. 2007. Proc. Natl. Acad. Sci. USA104, 5668.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable