400084

HIF Prolyl Hydroxylase Inhibitor

• 동의어(들): HIF Prolyl Hydroxylase Inhibitor
• 실험식(Hill 표기법): C₂₁H₁₆ClN₃O
• CAS Number: 385786-48-1
• Molecular Weight: 361.82
• UNSPSC 코드: 12352200
• NACRES: NA.54

속성

• 분석: ≥95% (HPLC)
• Quality Level: 100
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: tan
• solubility: DMSO: 50 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

A cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC₅₀ = 2 µM in a cell-based assay using a reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to luciferase. This compound (5 µM) is shown to significantly stabilize HIF-1α in vitro and upregulate known HIF target genes, Epo and VEGF, in SH-SY5Y human neuroblastoma cell lines. It also exerts a neuroprotective effect (IC₅₀ = 0.25 µM in an oxidative stress model using cortical neurons.

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Smirnova, N.A., et al. 2010. Chem. Biol.4, 380.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable