353905

Glutathione Monoethyl Ester

>90% (TLC), solid, GSH-MEE transport, Calbiochem^®

• 동의어(들): Glutathione Monoethyl Ester, γ-GCE, L-γ-Glutamyl-L-cysteinyl Ethyl Glycinate, GSH-MEE
• 실험식(Hill 표기법): C₁₂H₂₁N₃O₆S
• CAS Number: 118421-50-4
• Molecular Weight: 335.38
• MDL number: MFCD00156117
• UNSPSC 코드: 12352209
• NACRES: NA.77

속성

• 제품명: Glutathione Monoethyl Ester, Cell-permeable derivative of glutathione (GSH) that undergoes hydrolysis by intracellular esterases to release GSH.
• Quality Level: 100
• 분석: >90% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic)
• 색상: white
• solubility: water: 50 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C
• SMILES string: SC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)OCC
• InChI: 1S/C12H21N3O6S/c1-2-21-10(17)5-14-11(18)8(6-22)15-9(16)4-3-7(13)12(19)20/h7-8,22H,2-6,13H2,1H3,(H,14,18)(H,15,16)(H,19,20)/t7-,8-/m0/s1
• InChI key: JKRODHBGNBKZLE-YUMQZZPRSA-N

설명

일반 설명

Cell-permeable derivative of glutathione (GSH) that undergoes hydrolysis by intracellular esterases thereby increasing intracellular GSH concentration in many tissues and cell types. Effective transport of GSH-MEE has been used to protect cells against radiation damage, oxidants and various toxic compounds including heavy metals. A protective agent against cellular damage, such as cataracts and mitochondrial degeneration.

Cell-permeable derivative of glutathione (GSH) that undergoes hydrolysis by intracellular esterases to release GSH. Effective transport of GSH-MEE has been used to protect cells against damage from radiation, oxidants, and various toxic compounds including heavy metals. A protective agent against cellular damage such as in cataracts and mitochondrial degeneration.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
Effective transport of GSH-MEE

Product does not compete with ATP.

Reversible: no

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Unstable in solution; reconstitute just prior to use.

기타 정보

Grattagliano, I., et al. 1995. J. Pharmacol. Exp. Ther. 272, 484.
Martensson, J., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 317.
Anderson, M.E., and Meister, A. 1989. Anal. Biochem. 183, 16.
Anderson, M.E., et al. 1985. Arch. Biochem. Biophys. 239, 538.
Wellner, V.P., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 4732.
Puri, R.N., and Meister, A. 1983. Proc. Natl. Acad. Sci. USA 80, 5258.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable