343781-M

ω-Conotoxin GVIA, Conus geographus

A neurotoxin that acts as an antagonist of voltage-activated N-type Ca²⁺ channels and of neurotransmitter release at neuronal synapses.

• 동의어(들): ω-Conotoxin GVIA, Conus geographus, ω-CgTx GVIA
• 실험식(Hill 표기법): C₁₂₀H₁₈₂N₃₈O₄₃S₆
• CAS Number: 106375-28-4
• Molecular Weight: 3037.35
• MDL number: MFCD00076620
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: lyophilized
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• solubility: water: 250 μg/mL; aqueous buffer: soluble
• 저장 온도: −20°C

설명

일반 설명

A neurotoxin that acts as an antagonist of voltage-activated N-type Ca²⁺ channels and of neurotransmitter release at neuronal synapses. Its antagonistic activity is attributed to a tyrosine residue at position 13. Does not bind to dihydropyridine- or verapamil-binding sites. Also reported to inhibit ATP-induced inward currents mediated by P2X2/X3 receptors (IC₅₀ = 21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors).

생화학적/생리학적 작용

Primary Target
Voltage-activated N-type Ca2+ channels

Target IC₅₀: 21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors

경고

Toxicity: Highly Toxic (H)

서열

H-Cys¹-Lys-Ser-Hyp-Gly-Ser-Ser-Cys⁸-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys¹⁵-Cys¹⁶-Arg-Ser-Cys¹⁹-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys²⁶-Tyr-NH₂ (disulfide bonds: 1 → 16; 8 → 19; 15 → 26)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

기타 정보

Lalo, U.V., et al. 2001. Brain Res. Bull.54, 507.
Kim, J.I., et al. 1995. Biochem. Biophys. Res. Commun. 206, 449.
Abbott, J.R., and Litzinger, M.J. 1994. Int. J. Dev. Neurosci. 12, 43.
Olivera, B.M., et al. 1991. J. Biol. Chem.266, 22067.
Protti, D.A., et al. 1991. Brain Res.557, 336.
Werth, J.L., et al. 1991. Mol. Pharmacol.40, 742.
Koyano, K., et al. 1987. Eur. J. Pharmacol.135, 337.
Abe, T., et al. 1986. Neurosci. Lett.71, 203.

법적 정보

Not available for sale outside of the United States.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable