239822

CXCR4 Antagonist III

The CXCR4 Antagonist III controls the biological activity of CXCR4. This small molecule/inhibitor is primarily used for Biochemicals applications.

• 동의어(들): CXCR4 Antagonist III, N²-(4-((3-(Cyclohexylamino)propylamino)methyl)benzyl)-N⁴-(piperidin-4-yl) quinazoline-2,4-diamine, 2HCl, Fusin Antagonist III
• 실험식(Hill 표기법): C₃₀H₄₃N₇ · 2HCl
• CAS Number: 1357819-69-2
• Molecular Weight: 574.63
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic); protect from light
• 색상: white
• solubility: DMSO: 25 mg/mL; water: 25 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: C1(N=C(NCC2=CC=C(CNCCCNC3CCCCC3)C=C2)N=C4NC5CCNCC5)=C4C=CC=C1

설명

일반 설명

A cell-permeable quinazoline compound that acts as a potent and reversible CXCR4 antagonist (IC₅₀ = 36.2 nM for SDF-1/CXCL12 binding to hCXCR4-transfected HEK293 membrane) with selectivity over closely related human chemokine receptors CXCR2, CCR2, CCR4 and CCR5 (IC₅₀ >10 µM). Shown to inhibit CXCL12-induced Ca²⁺-mobilization and cell migration in hCXCR4-HEK293 cells (IC₅₀ = 100.1 and 41 nM, respectively), and rapidly mobilize CXCR4⁺, CD34⁺ and CD133⁺ stem cells from bone marrow in C57BL/6 male mice (6 mg/kg, s.c).

생화학적/생리학적 작용

Cell permeable: yes

Reversible: yes

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (20°C). Stock solutions are stable for up to 6 months at -20°C.

기타 정보

Wu, C.H., et al. 2012. Chem. Med. Chem.7, In press.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable