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Merck
모든 사진(1)

주요 문서

234599

Sigma-Aldrich

Conduritol B Epoxide

≥98% (HPLC), solid, Glucocerebrosidase inhibitor, Calbiochem®

동의어(들):

Conduritol B Epoxide, CBE, 1,2-Anhydro-myo-inositol

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About This Item

실험식(Hill 표기법):
C6H10O5
CAS Number:
Molecular Weight:
162.14
MDL number:
UNSPSC 코드:
12352119
NACRES:
NA.77

제품명

Conduritol B Epoxide, Conduritol B Epoxide, CAS 6090-95-5, is an irreversible Inhibitor of glucocerebrosidase in neurons. Also inhibits α-glucosidase activity in a variety of species.

Quality Level

분석

≥98% (HPLC)

양식

solid

제조업체/상표

Calbiochem®

저장 조건

OK to freeze
desiccated

색상

white

solubility

DMSO: soluble
water: soluble

배송 상태

ambient

저장 온도

−20°C

SMILES string

O1[C@@H]2[C@H]1[C@@H]([C@H]([C@@H]([C@H]2O)O)O)O

InChI

1S/C6H10O5/c7-1-2(8)4(10)6-5(11-6)3(1)9/h1-10H/t1-,2-,3+,4+,5-,6+/m0/s1

InChI key

ZHMWOVGZCINIHW-FTYOSCRSSA-N

일반 설명

Inhibits α-glucosidase activity in mammals, snails, sweet almonds and yeast. An irreversible, potent, and specific inhibitor of glucocerebrosidase in cultured neurons. Has also been shown to inhibit α-glucosidase from yeast, and rabbit intestinal sucrase-isomaltase complex.
Inhibits α-glucosidase activity in mammals, snails, sweet almonds, and yeast. An irreversible, potent, and specific inhibitor of glucocerebrosidase in cultured neurons. Has also been shown to inhibit α-glucosidase from yeast and rabbit intestinal sucrase-isomaltase complex.

생화학적/생리학적 작용

Cell permeable: no
Primary Target
α-glucosidase
Product does not compete with ATP.
Reversible: no

경고

Toxicity: Harmful (C)

재구성

Unstable in solution; reconstitute just prior to use.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Azucena Perez-Canamas et al.
Brain communications, 3(1), fcaa200-fcaa200 (2021-04-03)
TMEM106B is a transmembrane protein localized to the endo-lysosomal compartment. Genome-wide association studies have identified TMEM106B as a risk modifier of Alzheimer's disease and frontotemporal lobar degeneration, especially with progranulin haploinsufficiency. We recently demonstrated that TMEM106B loss rescues progranulin null
Electra Brunialti et al.
Journal of neuroinflammation, 18(1), 220-220 (2021-09-24)
Homozygotic mutations in the GBA gene cause Gaucher's disease; moreover, both patients and heterozygotic carriers have been associated with 20- to 30-fold increased risk of developing Parkinson's disease. In homozygosis, these mutations impair the activity of β-glucocerebrosidase, the enzyme encoded

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