23-049-M

p38/JTV-1 Protein, 10 µg

Full length, recombinant human p38/JTV-1. N-terminal cMyc, GST-tagged. For use in Enzyme Assays. Functions as a substrate in ubiquitination assays.

• 동의어(들): Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, AIMP2, Multisynthase complex auxiliary component p38
• UNSPSC 코드: 12352202
• eCl@ss: 32160405
• NACRES: NA.41

속성

• 생물학적 소스: human
• Quality Level: 100; 300
• 재조합: expressed in Sf21 cells
• 제조업체/상표: Upstate^®
• 기술: activity assay: suitable
• GenBank 수납 번호: BC002853

설명

일반 설명

p38/JTV-1 is a scaffold required for the assembly and stability of the multi-tRNA synthetase complex, an essential enzyme that ligates specific amino acids to tRNAs before protein synthesis. It plays a pivotal role in the control of cell proliferation and has been shown to interact with FUSE binding protein, stimulating its ubquitination and degradation and leading to the down-regulation of the transcription factor c-Myc which is required for differentiation of functional alveolar type II cells. Genetic disruption of p38/JTV-1 in mice has been observed to cause neonatal lethality.

p38/JTV-1 is ubiquitinated by the E3 ligase Parkin, leading to its proteosomal degradation. It has been shown to accumulate in Parkin-deficient mice and in the brain tissue of patients with hereditary Parkinson’s, suggesting that it may play a role in the pathogenicity of this disease.

애플리케이션

Ubiquitination Cascade Comoponent: Substrate

물리적 형태

Purified using immobilized metal affinity chromatography.

법적 정보

GenBank is a registered trademark of United States Department of Health and Human Services

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H317
• 예방조치 성명서: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable