208900

Calpastatin, Human, Recombinant, Domain I

Domain I of human calpastatin.

• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• Quality Level: 100
• 형태: lyophilized solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: white
• solubility: aqueous buffer: 1 mg/mL; water: 1 mg/mL
• 배송 상태: wet ice
• 저장 온도: −20°C

설명

일반 설명

An endogenous protease inhibitor that acts specifically on Calpain I (Cat. No. 208712), a Ca²⁺-dependent cysteine protease. Widely distributed in mammalian and avian cells. Has better inhibitory action than Calpain Inhibitor I (Cat. No. 208719) and Calpain Inhibitor II (Cat. No. 208721). Calpastatin corresponds to domain I of human calpastatin. The inhibitory sequence of human domain I consists of at least 18 amino acid residues.

Domain I of human calpastatin. Endogenous protease inhibitor that acts specifically on Calpain-1 (Cat. No. 208712). Exhibits greater inhibitory potency than calpain inhibitors I and II.

생화학적/생리학적 작용

50 nM completely inhibits the activity of 7.5 µg/ml calpain I

Cell permeable: no

Primary Target
calpain-1

Product does not compete with ATP.

Reversible: no

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

분석 메모

homogeneous by SDS-PAGE

기타 정보

Salamino, F., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1326.
Uemori, T., et al. 1990. Biochem. Biophys. Res. Commun. 166, 1485.
Asada, K., et al. 1989. J. Enzyme Inhib.3, 49.

법적 정보

Not available for sale in Japan.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable