208724

Calpain Inhibitor IV

The Calpain Inhibitor IV controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 동의어(들): Calpain Inhibitor IV, Z-LLY-FMK
• 실험식(Hill 표기법): C₃₀H₄₀FN₃O₆
• Molecular Weight: 557.65
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated
• 색상: white to pale yellow
• solubility: DMSO: 25 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

A potent, cell-permeable and irreversible inhibitor of calpain II (k₂ = 28,900 M^-1s^-1). Also acts as an inhibitor of cathepsin L (k₂ = 680,000 M^-1s^-1).

A potent, cell-permeable, and irreversible inhibitor of calpain II (k₂ = 28,900 M^-1s^-1). Also acts as an inhibitor of cathepsin L (k₂ = 680,000 M^-1s^-1).

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
calpain 2

Product does not compete with ATP.

Reversible: no

k₂ = 28,900 M⁻¹s⁻¹ in the inhibition of calpain II; k2 = 680,000 M⁻¹s⁻¹ in the inhibition of cathepsin L

경고

Toxicity: Standard Handling (A)

서열

Z-Leu-Leu-Tyr-CH₂F

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

분석 메모

single spot by TLC

기타 정보

Dutt, P., et al. 1998. FEBS Lett. 436, 367.
Angliker, H., et al. 1992. J. Med. Chem. 35, 216.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable