203996

N-Butyldeoxynojirimycin, Hydrochloride

A non-hormonal, alkylated iminosugar that acts as a transition state analog inhibitor of ceramide-specific glycosyltransferases and ER α-glucosidases I and II.

• 동의어(들): N-Butyldeoxynojirimycin, Hydrochloride, NB-DNJ, HCl, N-Butyl-DNJ, HCl
• 실험식(Hill 표기법): C₁₀H₂₁NO₄ · xHCl
• CAS Number: 72599-27-0
• Molecular Weight: 219.28 (free base basis)
• MDL number: MFCD00272581
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic); protect from light
• 색상: white
• solubility: water: 1 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1
• InChI key: UQRORFVVSGFNRO-UTINFBMNSA-N

설명

일반 설명

A non-hormonal, alkylated imino sugar that acts as a transition state analog inhibitor of ceramide-specific glycosyltransferases and ER α-glucosidases I and II. Displays broad-spectrum anti-viral effects by inhibiting the processing of viral surface glycoproteins. Shown to reversibly induce infertility in male mammals.

A non-hormonal, alkylated iminosugar that acts as a transition state analog inhibitor of ceramide-specific glycosyltransferases and ER α-glucosidases I and II. Displays a broad-spectrum anti-viral activity by aiding the misfolding of glycoproteins. Shown to reversibly induce infertility in male mammals. Does not inhibit cell proliferation.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
Ceramide-specific glycosyltransferases

Product does not compete with ATP.

Reversible: yes

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

기타 정보

Dwek, R.A., et al. 2002. Nat. Rev. Drug Discovery1, 65.
van der Spoel, A.C., et al. 2002. Proc. Natl. Acad. Sci. USA99, 17173.
Platt, F.M., et al. 1997. Science276, 428.
Block, T.M., et al. 1994. Proc. Natl. Acad. Sci. USA91, 2235.
Platt, F.M., et al. 1994. J. Biol. Chem.269, 8362.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable