203811

Bryostatin 1

≥98% (HPLC), solid,film, antitumor agent, Calbiochem^®

• 동의어(들): Bryostatin 1, Bryo 1, PKC Activator VII, PKC Activator VI
• 실험식(Hill 표기법): C₄₇H₆₈O₁₇
• CAS Number: 83314-01-6
• Molecular Weight: 905.03
• MDL number: MFCD00893832
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• product name: Bryostatin 1, A macrocyclic lactone with antitumor properties.
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: film; solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white to colorless
• solubility: DMSO: 25 mg/mL; ethanol: 25 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C
• InChI: 1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35?,36?,37?,38?,43+,46+,47-/m1/s1
• InChI key: MJQUEDHRCUIRLF-BXOMOELISA-N

설명

일반 설명

A macrocyclic lactone that exhibits anti-tumor properties. Potently activates protein kinase C and exhibits high binding affinity (K_i = 1.35 nM). Effectively translocates protein kinase C (PKC) isozymes α, β, and ε and induces a biphasic, concentration-dependent, down-regulation of PKC δ. Reported to compete with phorbol esters in binding to PKC. Stimulates protein kinase D (PKD) activity in a biphasic, PKC-dependent manner in intact cells. Also activates Ras in Jurkat T cells and in rat2 cells.

A macrocyclic lactone with antitumor properties. Potently activates protein kinase C and exhibits a high binding affinity (K_i = 1.35 nM). Effectively translocates and down-regulates PKC isozymes α, δ, and ε. Induces a biphasic activation of PKD through a PKC-dependent pathway in intact cells. Also shown to activate Ras in Jurkat T cells and in rat2 cells.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
Protein kinase C

Product does not compete with ATP.

Reversible: no

Target K_i: 1.35 nM for protein kinase C

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Clamp, A., and Jayson, G. 2002. Anticancer Drugs13, 673.
Lorenzo, P.S., et al. 1999. Cancer Res.59, 6137.
Wang, Q.J., et al. 1999. J. Biol. Chem.274, 37233.
Wender, P.A., et al. 1998. Proc. Natl. Acad. Sci. USA95, 6624.
Matthews, S.A., et al. 1997. J. Biol. Chem.272, 20245.
Szallasi, Z., et al. 1994. Mol. Pharmacol.46, 840.
Berkow, R.L., and Kratt, A.S. 1985. Biochem. Biophys. Res. Commun.3, 1109.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable