189826

5-Aza-2′-Deoxycytidine

InSolution, ≥98%, DNA methyltransferase inhibitor

• 동의어(들): InSolution 5-Aza-2′-Deoxycytidine, Decitabine
• 실험식(Hill 표기법): C₈H₁₂N₄O₄
• CAS Number: 2353-33-5
• Molecular Weight: 228.21
• MDL number: MFCD00043011
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: liquid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic); protect from light
• 배송 상태: ambient
• 저장 온도: −20°C
• InChI: 1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)
• InChI key: XAUDJQYHKZQPEU-UHFFFAOYSA-N

설명

일반 설명

A cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines. Also enhances apoptosis induced by HDAC (Histone Deacetylase) inhibitors. The solid form of this compound (Cat. No. 189825) is also available.

포장

Packaged under inert gas

경고

Toxicity: Regulatory Review (Z)

물리적 형태

A 100 mM (10 mg/438 µl) solution of 5-Aza-2ʹ-Deoxycytidine (Cat. No. 189825) in DMSO.

기타 정보

Eggert, A., et al. 2001. Cancer Res.61, 1314.
Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun.288, 921.
Zhu, W.G., et al. 2001. Cancer Res.61, 1327.
Hopkins-Donaldson, S., et al. 2000. Cancer Res.60, 4315.
Haaf, T. 1995. Pharmacol. Ther.65, 19.
Jones, P.A., and Taylor, S.M. 1980. Cell20, 85.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany