176708

Angiostatin K1-3, Human, Recombinant, E. coli

Angiostatin K1-3 is a recombinant form expressed in E. coli as a single, non-glycosylated polypeptide chain of 259 amino acids. A specific inhibitor of endothelial cell growth and angiogenesis.

• 동의어(들): Ang K1-3, K1-3, rHuAng K1-3
• UNSPSC 코드: 12352203
• NACRES: NA.77

속성

• 재조합: expressed in E. coli
• Quality Level: 100
• 분석: ≥95% (HPLC and SDS-PAGE)
• 형태: lyophilized powder
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; avoid repeated freeze/thaw cycles
• solubility: aqueous buffer containing 0.1% BSA: soluble; water: soluble
• 배송 상태: wet ice
• 저장 온도: −20°C

설명

일반 설명

Recombinant, human angiostatin expressed in E. coli as a single, nonglycosylated polypeptide chain containing 259 amino acids. Represents a proteolytic fragment containing the first three kringle structures of plasminogen. Acts as a specific inhibitor of endothelial cell growth and angiogenesis. Displays increased inhibitory activity (ED₅₀=70 nM) relative to kringles 1-4 (ED₅₀=135 nm).

경고

Toxicity: Standard Handling (A)

물리적 형태

Lyophilized from 20 mM Sodium Acetate, 4% Mannitol, pH 5.5.

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

기타 정보

Cao, R., et al. 1999. Proc. Natl. Acad. Sci. USA96, 5728.
Cao, E., et al. 1997. J. Biol. Chem.272, 22924.
Sim, B.K., et al. 1997. Cancer Res.57, 1329.
Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun.236, 651.
O′Rieilly, M.S., et al. 1994. Cell79, 315.
Peterson, T.E., et al. 1990. J. Biol. Chem.265, 6104.
Forsgren, M., et al. 1987. FEBS Lett.213, 254.
Malinowski, D.P., et al. 1984. Biochemistry23, 4243.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1