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Merck
모든 사진(1)

Key Documents

14-327-M

Sigma-Aldrich

JNK1α1/SAPK1c Protein, active, 10 µg

Active, recombinant full-length human JNK1α1/SAPK1c with an N-terminal His-tag, for use in Kinase Assays.

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모든 사진(1)

About This Item

UNSPSC 코드:
12352200
eCl@ss:
32160405
NACRES:
NA.41

생물학적 소스

human

Quality Level

100

재조합

expressed in Sf21 cells

제품 라인

Upstate®

특이 활성도

(For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)

분자량

Mw 45 kDa

정제법

(Ni2+/NTA-agarose)

종 반응성

human

제조업체/상표

Upstate®

기술

activity assay: suitable (kinase)

수납 번호(accession number)

 (FUNCTION: SwissProt: P45983 # JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta- 2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. )
NM_002750.2

NCBI 수납 번호

NM_002750.2
NM_139046.1
NM_139047.1
NM_139049.1

UniProt 수납 번호

P45983

유전자 정보

human ... MAPK8(5599)

일반 설명

Recombinant full-length human JNK1α1/SAPK1c with an N-terminal His-tag

포장

10 μg vial
Also available in 250μg size (catalog number 14-327M).
Also available in 10 μg size and in bulk

품질

Routinely evaluated by phosphorylation of ATF2 (amino acids 19-96)

표적 설명

JNK1α1/SAPK1c

기타 정보

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

법적 정보

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H317

Hazard Classifications

Skin Sens. 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Girish V Putcha et al.
Neuron, 38(6), 899-914 (2003-06-24)
Trophic factor deprivation (TFD) activates c-Jun N-terminal kinases (JNKs), culminating in coordinate AP1-dependent transactivation of the BH3-only BCL-2 proteins BIM(EL) and HRK, which in turn are critical for BAX-dependent cytochrome c release, caspase activation, and apoptosis. Here, we report that
Y Zhang et al.
The Journal of biological chemistry, 276(24), 20913-20923 (2001-03-30)
Ultraviolet light A (UVA) plays an important role in the etiology of human skin cancer, and UVA-induced signal transduction has a critical role in UVA-induced skin carcinogenesis. The upstream signaling pathways leading to p70(S6K) phosphorylation and activation are not well
S Gupta et al.
The EMBO journal, 15(11), 2760-2770 (1996-06-03)
The JNK protein kinase is a member of the MAP kinase group that is activated in response to dual phosphorylation on threonine and tyrosine. Ten JNK isoforms were identified in human brain by molecular cloning. These protein kinases correspond to
Y Fleming et al.
The Biochemical journal, 352 Pt 1, 145-154 (2000-11-04)
Stress-activated protein kinase 1 (SAPK1), also called c-Jun N-terminal kinase (JNK), becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses. Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif
S Gupta et al.
Science (New York, N.Y.), 267(5196), 389-393 (1995-01-20)
Treatment of cells with pro-inflammatory cytokines or ultraviolet radiation causes activation of the c-Jun NH2-terminal protein kinase (JNK). Activating transcription factor-2 (ATF2) was found to be a target of the JNK signal transduction pathway. ATF2 was phosphorylated by JNK on

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