126850

α₁-PDX, Human, Recombinant, E. coli

Recombinant protein derived from the bioengineered human α1-antitrypsin gene fused to a His•Tag sequence and a FLAG-tag.

• 동의어(들): α₁-Antitrypsin Portland
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥80% (SDS-PAGE)
• 양식: lyophilized solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: do not freeze
• solubility: water: 2.5 mg/mL
• 배송 상태: wet ice
• 저장 온도: 2-8°C

설명

일반 설명

Recombinant protein derived from the bioengineered human α1-antitrypsin gene fused to a His·Tag and a FLAG·Tag. Contains a minimal furin consensus sequence, RXXR, that effectively blocks the furin-dependent processing of protein precursors (K_i = 600 pM). α1-PDX can be used in extracellular applications to block the processing of furin substrates. α1-PDX has been shown to inhibit the processing of biologically significant proteins including viral envelope glycoproteins, bacterial toxins, receptors, and growth factors.

Recombinant protein derived from the bioengineered human α₁-antitrypsin gene fused to a His•Tag sequence and a FLAG-tag. Contains a minimal furin consensus sequence, RXXR, that effectively blocks the furin-dependent processing of protein precursors (K_i = 600 pM). Extracellular application of α₁-PDX can be used to inhibit the processing of biologically significant proteins including viral envelope glycoproteins, bacterial toxins, receptors, and growth factors. Useful for in vivo and in vitro furin inhibition assays.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
Furin-dependent processing of protein precursors

Product does not compete with ATP.

Reversible: no

Target K_i: 600 pM against furin-dependent processing of protein precursors

포장

Please refer to vial label for lot-specific concentration.

경고

Toxicity: Standard Handling (A)

물리적 형태

Lyophilized from PBS.

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Bassi, D.E., et al. 2001. Proc. Natl. Acad. Sci. USA98, 10326.
Jean, F., et al. 2000. Proc. Natl. Acad. Sci. USA97, 2864.
Jean, F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 7293.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable