07-1213
Anti-IP3 Receptor 1 Antibody
serum, from rabbit
동의어(들):
IP3 receptor isoform 1, Type 1 InsP3 receptor, Type 1 inositol 1,4,5-trisphosphate receptor, inositol 1,4,5-triphosphate receptor, type 1, spinocerebellar ataxia 15, spinocerebellar ataxia 16
로그인조직 및 계약 가격 보기
모든 사진(2)
About This Item
UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41
추천 제품
생물학적 소스
rabbit
Quality Level
항체 형태
serum
항체 생산 유형
primary antibodies
클론
polyclonal
종 반응성
mouse, human
종 반응성(상동성에 의해 예측)
canine, rat
기술
immunohistochemistry: suitable (paraffin)
western blot: suitable
동형
IgG
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
dog ... Itpr1(476548)
human ... ITPR1(3708)
mouse ... Itpr1(16438)
rat ... Itpr1(25262)
일반 설명
IP3 Receptor 1 is an intracellular channel that when stimulated by inositol 1,4,5-triphosphate mediates the release of calcium from the endoplasmic reticulum. Defects within the gene ITPR1 cause a group of cerebellar disorders known as spinocerebellar ataxia type 15 (SCA15). This receptor is widely expressed in tissue.
특이성
The antibody reacts with the 300 kDa IP3 Receptor 1 protein.
면역원
Synthetic peptide from the N-terminal of human IP3 Receptor 1.
애플리케이션
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected IP3 Receptor 1 in mouse cerebellum tissue.
Research Category
Signaling
Signaling
Research Sub Category
Lipid Signaling
Lipid Signaling
This Anti-IP3 Receptor 1 Antibody is validated for use in IH(P), WB for the detection of IP3 Receptor 1.
품질
Evaluated by Western Blot in C2C12 cell lysates.
Western Blot Analysis: 1:500 dilution of this lot detected IP3 RECPT 1 on 10 ug of C2C12 lysates.
Western Blot Analysis: 1:500 dilution of this lot detected IP3 RECPT 1 on 10 ug of C2C12 lysates.
표적 설명
Approx. 300 kDa
결합
Replaces: AB9072
물리적 형태
Rabbit serum. Liquid
Unpurified rabbit serum
저장 및 안정성
Maintain at -20°C in undiluted aliquots for up to 1 year date of receipt. Avoid repeated freeze/thaw cycles.
분석 메모
Control
C2C12 cell lysates
C2C12 cell lysates
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Michael R Butler et al.
The Journal of biological chemistry, 292(27), 11189-11205 (2017-05-13)
Endoplasmic reticulum (ER) stress and mislocalization of improperly folded proteins have been shown to contribute to photoreceptor death in models of inherited retinal degenerative diseases. In particular, mice with cone cyclic nucleotide-gated (CNG) channel deficiency, a model for achromatopsia, display
Xiang Liu et al.
Molecular medicine reports, 14(6), 5435-5442 (2016-11-15)
Isoflurane is a commonly used inhaled anesthetic, which induces apoptosis of SH‑SY5Y cells in a dose‑ and time‑dependent manner; however, the underlying mechanisms remain unknown. The authors of the present study hypothesized that a mutation in β‑amyloid precursor protein (APP)
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