05-615

Anti-SUV39H1 Antibody, clone MG44

ascites fluid, clone MG44, Upstate^®

• 동의어(들): KMT1A
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: ascites fluid
• 항체 생산 유형: primary antibodies
• 클론: MG44, monoclonal
• 종 반응성: mouse, human
• 제조업체/상표: Upstate^®
• 기술: ChIP: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• 동형: IgG
• NCBI 수납 번호: NM_003173.2
• UniProt 수납 번호: O43463
• 배송 상태: dry ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... SUV39H1(6839)

설명

일반 설명

Post -translational modification of histones, such as phosphorylation, acetylation, and methylation, are crucial for chromatin remodeling. SUV39H1 and Suv39h1 are the human and mouse homologs of Drosophila Su(var)3-9 protein, respectively. These proteins selectively methylate histone H3 at lysine 9 creating a high-affinity binding site for the HP1 proteins (heterochromatin protein 1). HP1 proteins are known to interact with transcription suppressor proteins, suggesting that the interactions with SUV39H1 and methylated histone H3 mediate a silence effect on the transcription of target genes. Furthermore, over-expression of SUV39H1 in HeLa cells causes a redistribution of endogenous HP1 proteins and growth retardation, suggesting that SUV39H1-mediated modulation of heterochromatin can impair cell cycle progression.

특이성

Recognizes SUV39H1.

면역원

MBP fusion protein corresponding to residues 1-412 of human SUV39H1

애플리케이션

Anti-SUV39H1 Antibody, clone MG44 is a Mouse Monoclonal Antibody for detection of SUV39H1 also known as KMT1A, Histone H3-K9 Methyltransferase 1 & has been validated in ChIP, IP & WB.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Histones

Chromatin Biology

품질

routinely evaluated by immunoblot on U2OS cells lysed in RIPA with 0.1% SDS and sonicated

표적 설명

50 kDa

결합

Replaces: MABE552

물리적 형태

Protein G Purified immunoglobulin in Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.

Unpurified

저장 및 안정성

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

분석 메모

Control
U2OS cell lysate

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

법적 정보

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1