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Merck
모든 사진(4)

Key Documents

05-389

Sigma-Aldrich

Anti-Rac1 Antibody, clone 23A8

clone 23A8, Upstate®, from mouse

동의어(들):

Anti-Rac1

로그인조직 및 계약 가격 보기


About This Item

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41

생물학적 소스

mouse

Quality Level

항체 형태

purified immunoglobulin

항체 생산 유형

primary antibodies

클론

23A8, monoclonal

종 반응성

rat, human, mouse

포장

antibody small pack of 25 μg

제조업체/상표

Upstate®

기술

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

동형

IgG2b

NCBI 수납 번호

UniProt 수납 번호

배송 상태

ambient

타겟 번역 후 변형

unmodified

유전자 정보

human ... RAC1(5879)

일반 설명

Rac1 is a member of a RhoGTPase subfamily (Rac1-Rac4) that transduces extracellular signals from G-coupled protein receptors (GPCR), integrins and growth factor receptors to effector molecules that modulate multiple signaling pathways. While Rac1 supports the activation of MAPkinase pathways and gene activation, it’s most important functions include the regulation of cytoskeletal structures. Together with Rho (regulator of stress fibers) and Cdc42 (regulator of filopodia), Rac modulates the formation of focal adhesion (FA) complexes; membrane ruffles and lamellipodia that contribute to important cell functions related to cell attachment and movement.

특이성

Recognizes Rac1; Strong Rac1 preference with slight Rac2 cross-reactivity.

면역원

Recombinant protein containing the full length human Rac

애플리케이션

Research Category
Signaling
Research Sub Category
Cytoskeletal Signaling

G-proteins
This Anti-Rac1 Antibody, clone 23A8 has been published in more than 40 citations and validated for use in Immunohistochemistry (IHC), Immunoprecipitation (IP) and Western Blotting (WB) for the detection of Rac1 protein.

품질

routinely evaluated by immunoblot on rat brain microsomal protein preparation

표적 설명

21 kDa

물리적 형태

Format: Purified
Protein G Purified
Protein G Purified immunoglobulin in Protein G Purified immunoglobulin in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%

저장 및 안정성

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

분석 메모

Control
Immunoblot/Immunoprecipitation: Rat brain microsomal protein preparation
Immunohistochemistry: Rat brain sections

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

법적 정보

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells.
Villalba, M, et al.
The Journal of cell biology, 155, 331-338 (2001)
Expression of NADPH oxidase in rabbit corneal epithelial and stromal cells in culture.
O'Brien, WJ; Krema, C; Heimann, T; Zhao, H
Investigative Ophthalmology & Visual Science null
Evaluation of Rho family small G-protein activity induced by integrin ligation on human leukocytes.
Angela Gismondi, Fabrizio Mainiero, Angela Santoni
Methods in Molecular Biology null
H N Kovacic et al.
The Journal of biological chemistry, 276(49), 45856-45861 (2001-10-05)
Rac1 has been shown to activate a NADPH oxidase complex producing superoxide anions in a variety of mammalian cell types. We evaluated the impact of Rac1-induced reactive oxygen species production on the turnover of Rac1 itself in human aortic endothelial
Androgen-stimulated DNA synthesis and cytoskeletal changes in fibroblasts by a nontranscriptional receptor action
Castoria, G., et al
The Journal of cell biology, 161, 547-556 (2003)

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