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Merck
모든 사진(1)

주요 문서

04-281

Sigma-Aldrich

Anti-phospho-EGFR (Thr669) Antibody, clone 5F10

clone 5F10, Upstate®, from mouse

동의어(들):

ERBB, ERBB1, epidermal growth factor receptor

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모든 사진(1)

About This Item

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41

생물학적 소스

mouse

Quality Level

100

항체 형태

purified immunoglobulin

항체 생산 유형

primary antibodies

클론

5F10, monoclonal

종 반응성

human

제조업체/상표

Upstate®

기술

western blot: suitable

동형

IgG1

NCBI 수납 번호

NM_005228.3
NM_201282.1
NM_201283.1
NM_201284.1

UniProt 수납 번호

P00533

배송 상태

wet ice

타겟 번역 후 변형

phosphorylation (pThr669)

유전자 정보

human ... EGFR(1956)

특이성

Recognizes EGFR when phosphorylated at Threonine 669.

면역원

KLH-conjugated synthetic peptide encompassing the surrounding amino acids of Thr 669 in human EGFR.

애플리케이션

Anti-phospho-EGFR (Thr669) Antibody, clone 5F10 detects level of phospho-EGFR (Thr669) & has been published & validated for use in WB.
Research Category
Signaling
Research Sub Category
Growth Factors & Receptors

품질

Routinely evaluated by immunoblot.

표적 설명

180 kDa

물리적 형태

100 µg of mouse monoclonal IgG1 liquid in 0.01 mg/ml PBS containing 0.09% sodium azide, PEG, and sucrose with 50 % glycerol.
Format: Purified
Thiophilic adsoption and size exclusion chromatography

저장 및 안정성

6 months at -20°C from date of shipment

분석 메모

Control
Includes PMA and pervanadate treated A431 cell lysate as a positive control

법적 정보

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

시험 성적서(COA)

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문서 라이브러리 방문

Cisplatin induces PKB/Akt activation and p38(MAPK) phosphorylation of the EGF receptor
Winograd-Katz, S E and Levitzki, A
Oncogene, 25, 7381-7390 (2006)
Mutational removal of the Thr669 and Ser671 phosphorylation sites alters substrate specificity and ligand-induced internalization of the epidermal growth factor receptor
Heisermann, G J, et al
The Journal of Biological Chemistry, 265, 12820-12827 (1990)
G J Heisermann et al.
The Journal of biological chemistry, 263(26), 13152-13158 (1988-09-15)
The epidermal growth factor (EGF) receptor is regulated by EGF-stimulated autophosphorylation and by phorbol ester-stimulated, protein kinase C (Ca2+/phospholipid-dependent enzyme) mediated phosphorylation at identified sites. The EGF receptor contains additional phosphorylation sites including a prominent phosphothreonine and several phosphoserines which
F Yan et al.
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Overexpression of DNMT1 and KIT is prevalent in lung cancer, yet the underlying molecular mechanisms are poorly understood. While the deregulated activation of DNMT1 or KIT has been implicated in lung cancer pathogenesis, whether and how DNMT1 and KIT orchestrate

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