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860476P

Avanti

1-desoxymethylsphinganine-d5

Name: 1-desoxymethylsphinganine-d5
Brand: AVANTI

1-desoxymethylsphinganine-d5 (m17:0), powder

동의어(들):

1-Deoxymethylsphinganine-d5

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모든 사진(1)

About This Item

실험식(Hill 표기법):

C₁₇H₃₂D₅NO

CAS Number:

1246298-43-0

Molecular Weight:

276.51

UNSPSC 코드:

12352211

NACRES:

NA.25

형태

powder

포장

pkg of 1 × 1 mg (860476P-1mg)

제조업체/상표

Avanti Research^™ - A Croda Brand 860476P

배송 상태

dry ice

저장 온도

−20°C

SMILES string

O[C@](CN)([H])CCCCCCCCCCCCCC(C([2H])([2H])[2H])([2H])[2H]

일반 설명

Desoxymethylsphinganine is a are the major sphingoid-base present in mammals.

애플리케이션

1-desoxymethylsphinganine-d5 may be used as an internal standard for the sphingoid analysis from plasma and tissue.

생화학적/생리학적 작용

Mutations in the palmitoyltransferase (SPT) in hereditary sensory neuropathy type 1 (HSAN-1), due to altered substrate specificity 1-desoxymethylsphinganine and 1-deoxy-sphinganine.

포장

5 mL Amber Glass Screw Cap Vial (860476P-1mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

시험 성적서(COA)

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문서 라이브러리 방문

Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1

Garofalo K, et al.

The Journal of Clinical Investigation, 121(12), 4735-4745 (2011)

Characterization of two mutations in the SPTLC1 subunit of serine palmitoyltransferase associated with hereditary sensory and autonomic neuropathy type I.

Annelies Rotthier et al.

Human mutation, 32(6), E2211-E2225 (2011-05-28)

Hereditary sensory and autonomic neuropathy type I (HSAN-I) is an axonal peripheral neuropathy leading to progressive distal sensory loss and severe ulcerations. Mutations in SPTLC1 and SPTLC2, encoding the two subunits of serine palmitoyltransferase (SPT), the enzyme catalyzing the first

Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids

Penno A, et al.

The Journal of Biological Chemistry, 285(15), 11178-11187 (2010)

FADS3 is a Δ14Z sphingoid base desaturase that contributes to gender differences in the human plasma sphingolipidome.

Gergely Karsai et al.

The Journal of biological chemistry, 295(7), 1889-1897 (2019-12-22)

Sphingolipids (SLs) are structurally diverse lipids that are defined by the presence of a long-chain base (LCB) backbone. Typically, LCBs contain a single Δ4E double bond (DB) (mostly d18:1), whereas the dienic LCB sphingadienine (d18:2) contains a second DB at

Biophysical properties of novel 1-deoxy-(dihydro) ceramides occurring in mammalian cells

Jimenez-Rojo N, et al.

Biophysical Journal, 107(12), 2850-2859 (2014)

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