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Merck
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주요 문서

850151P

Avanti

18:1 PI(4)P

Avanti Research - A Croda Brand 850151P, powder

동의어(들):

1,2-dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′-phosphate) (ammonium salt)

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About This Item

실험식(Hill 표기법):
C45H90N2O16P2
CAS Number:
Molecular Weight:
977.15
UNSPSC 코드:
51191904
NACRES:
NA.25

분석

>99% (TLC)

양식

powder

포장

pkg of 1 × 100 μg (with stopper and crimp cap (850151P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850151P-500ug))

제조업체/상표

Avanti Research - A Croda Brand 850151P

지질 유형

cardiolipins
phospholipids

배송 상태

dry ice

저장 온도

−20°C

SMILES string

[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+].[NH4+]

InChI

1S/C45H84O16P2.2H3N/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(46)57-35-37(59-39(47)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)36-58-63(55,56)61-45-42(50)40(48)44(41(49)43(45)51)60-62(52,53)54;;/h17-20,37,40-45,48-51H,3-16,21-36H2,1-2H3,(H,55,5

InChI key

XDKQBHORSIMQSB-QVUMANCCSA-N

일반 설명

18:1 PI(5)P (1,2-dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′-phosphate) is an ammonium salt of modified lipid which bears a double at the 9th carbon of dioleoyl group. Phosphatidylinositol 4-phosphate (PI-4-P) is an abundant phosphoinositide species present in the plasma membrane.
Inositol phospholipid species are membrane-bound signaling molecules that have been implicated in almost all aspects of cellular physiology, including cellular growth, metabolism, proliferation, and survival.

애플리케이션

18:1 PI(5)P (1,2-dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′-phosphate) (ammonium salt)) has been used in protein−lipid overlay assay. It may be used in small unilamellar vesicles for liposome flotation assays. It may also be used in different lipid binding specificity studies.

생화학적/생리학적 작용

Phosphatidylinositol 4-phosphate (PI-4-P) is an important factor, that is required for membrane traffic, polarized growth and cytoskeleton organization.

포장

2 mL Amber Serum Vial with Stopper and Crimp Cap (850151P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850151P-500ug)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

No data available

Flash Point (°C)

No data available


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시험 성적서(COA)

Lot/Batch Number

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이미 열람한 고객

Vikram Ghugtyal et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(28), 8644-8649 (2015-07-01)
The phospholipid phosphatidylinositol-4-phosphate [PI(4)P], generated at the Golgi and plasma membrane, has been implicated in many processes, including membrane traffic, yet its role in cell morphology changes, such as the budding to filamentous growth transition, is unknown. We show that
Chao-Yuan Yu et al.
Plant physiology, 183(1), 221-235 (2020-03-25)
Phosphoinositides function as lipid signals in plant development and stress tolerance by binding with partner proteins. We previously reported that Arabidopsis (Arabidopsis thaliana) phosphoinositide-specific phospholipase C2 functions in the endoplasmic reticulum (ER) stress response. However, the underlying molecular mechanisms of
Mark R Lundquist et al.
Molecular cell, 70(3), 531-544 (2018-05-05)
While the majority of phosphatidylinositol-4, 5-bisphosphate (PI-4, 5-P2) in mammalian cells is generated by the conversion of phosphatidylinositol-4-phosphate (PI-4-P) to PI-4, 5-P2, a small fraction can be made by phosphorylating phosphatidylinositol-5-phosphate (PI-5-P). The physiological relevance of this second pathway is
Lee Dolat et al.
The Journal of cell biology, 214(5), 517-527 (2016-08-24)
Macropinocytosis, the internalization of extracellular fluid and material by plasma membrane ruffles, is critical for antigen presentation, cell metabolism, and signaling. Macropinosomes mature through homotypic and heterotypic fusion with endosomes and ultimately merge with lysosomes. The molecular underpinnings of this

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