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모든 사진(2)

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700056P

Avanti

lathosterol-d7

Avanti Research™ - A Croda Brand

동의어(들):

5α-Cholest-7-en-3β-ol (25,26,26,26,27,27,27-d7)

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모든 사진(2)

About This Item

실험식(Hill 표기법):
C27H39D7O
CAS Number:
2260669-10-9
Molecular Weight:
393.70
MDL number:
MFCD22416731
UNSPSC 코드:
41141804
NACRES:
NA.25

분석

>99% (TLC)

양식

powder

포장

pkg of 1 × 1 mg (700056P-1mg)

제조업체/상표

Avanti Research™ - A Croda Brand

배송 상태

dry ice

저장 온도

−20°C

일반 설명

Lathosterol is a metabolite of cholesterol present in human breast milk. Lathosterol is catabolized by lathosterol 5-desaturase to 7-dehydrocholesterol, which is a precursor of cholesterol. Lathosterol-d7 is a deuterated derivative of lathosterol.

애플리케이션

Lathosterol-d7 has been used as an internal standard in gas chromatography-mass spectrometry (GC–MS) for the breast milk sterol quantification and in liquid chromatography high resolution mass spectrometry (LC–HRMS) analysis.

생화학적/생리학적 작용

Lathosterol levels are direct indicators of cholesterol levels and aid in decoding metabolism defects. Elevated levels of lathosterol is implicated in cerebrotendinous xanthomatosis (CTX) and lathosterolosis. The inactivation of enzyme lathosterol 5-desaturase (SC5D) leads to accumulation of lathosterol in lathosterolosis pathology.

포장

5 mL Amber Glass Screw Cap Vial (700056P-1mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

Flash Point (°F)

No data available

Flash Point (°C)

No data available

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Patrycja A Krakowiak et al.
Human molecular genetics, 12(13), 1631-1641 (2003-06-19)
Lathosterol 5-desaturase catalyzes the conversion of lathosterol to 7-dehydrocholesterol in the next to last step of cholesterol synthesis. Inborn errors of cholesterol synthesis underlie a group of human malformation syndromes including Smith-Lemli-Opitz syndrome, desmosterolosis, CHILD syndrome, CDPX2 and lathosterolosis. We
Alan H B Wu et al.
Clinica chimica acta; international journal of clinical chemistry, 430, 43-47 (2014-01-08)
The analysis of blood for β-sitosterol and campesterol is the measures of cholesterol absorption while lathosterol is a measure of cholesterol synthesis. The biological variability of β-sitosterol, campesterol, and lathosterol was measured using liquid-chromatography tandem mass spectrometry from a cohort

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