QBD10760

t-Boc-N-amido-dPEG^®₈-acid

>95% (HPLC)

• 동의어(들): t-Boc-N-amido-PEG₈-COOH, t-Boc-N-amido-PEG₈-acid, t-Boc-PEG-acid, BocNH-​PEG₈-​CH₂CH₂COOH
• 실험식(Hill 표기법): C₂₄H₄₇NO₁₂
• Molecular Weight: 541.63
• MDL number: MFCD13185254
• UNSPSC 코드: 12352106

속성

• 분석: >95% (HPLC)
• 형태: solid or viscous liquid
• 반응 적합성: reaction type: Pegylations
• 폴리머 구조: shape: linear; functionality: heterobifunctional
• 배송 상태: ambient
• 저장 온도: −20°C

설명

특징 및 장점

t-Boc-N-amido-dPEG₈-acid is a monodisperse PEG product that is useful for peptide synthesis. The 28-atoms-long dPEG spacer allows the introduction of a short, hydrophilic spacer onto either end of a peptide chain or on an amino acid side chain. The flexible dPEG spacer conjugates to peptides using conventional peptide synthesis chemistry. The Boc protecting group removes easily with acids such as trifluoroacetic acid (TFA), HF, and trifluoromethane sulfonic acid (TFMSA). Peptide PEGylation imparts water solubility to hydrophobic peptide chains, expands the PEG-peptide conjugates′ hydrodynamic volumes (thus decreasing renal clearance), and protects PEGylated peptides from proteolysis. The combination of decreased renal clearance and protection from proteolysis contributes to longer in vivo circulation times for PEGylated (as compared to non-PEGylated) peptides. Additionally, PEGylation diminishes a peptide′s antigenicity. This product is part of the t-Boc-N-amido-dPEG_n-acid (n=4, 8, 12, 24, 36) product series.

법적 정보

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681

dPEG is a registered trademark of Quanta BioDesign

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable