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Merck
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Key Documents

CAR-201

Sigma-Aldrich

Cardiolipin Liposomes

100% Cardiolipin (CL) (10mM)

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About This Item

UNSPSC 코드:
12352211
NACRES:
NA.25

Quality Level

구성

Phosphate buffered saline

농도

10 mM

불순물

100 mol % Cardiolipin

입자 크기

100 nm

pH

7.4

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일반 설명

Liposomes are extensively used to study the interaction of proteins, peptides and other molecules with the surface of a lipid membrane.

Cardiolipin (CL) is a unique phospholipid with an interesting chemical and ultrastructural characteristics. It is a highly acidic dimer of phosphatidylglycerol (PG) and phosphatidic acid (PA) containing four acyl chains, three glycerols and two phosphate headgroups. Due to deprotonation of one of these phosphate groups, cardiolipin is negatively charged in physiological pH.

Cardiolipin (CL) is known as a mitochondria-specific phospholipid and is intimately linked to mitochondrial bioenergetic processes. It plays a functional role in mitochondrial membrane stability and dynamics, as it interacts with a number of inner mitochondrial membrane metabolite carriers, enzymes and proteins. Extensive studies of phamacological, toxicological, and therapeutic effects have shown that the incorporation of doxorubicin in cardiolipin liposomes improved antitumor activity. It has been reported that cardiolipin-containing liposomes have lower cardiotoxicity associated with doxorubicin by alteriing the pharmacokinetics and tissue distribution of the drug.

Cardiolipin is a negatively charged lipid and provides two types of binding possibilities: binding at the surface and encapsulation deep within the membrane. Our catalog of cardiolipin lipids contains many different types of saturated and unsaturated cardiolipin based liposomes made from 0.5% up to 100% cardiolipin.

애플리케이션

Drug delivery
Lipid-protein interactions

저장 및 안정성

Liposomes should never be frozen. Liposomes should be stored in the dark at 4°C, except when brought to room temperature for brief periods prior to use.

Liposomes are made under sterile conditions. If you need to take multiple aliquots out of the vial, it is advised to take extreme care in not contaminating the vial. It is recommended to handle the vial under a sterile hood to maintain the sterility of the product. Liposomes should never be frozen. Ice crystals that form during freezing will rupture the lipid membrane of the liposomes and change the size of liposomes particles.

법적 정보

Cellsome is a trademark of Encapsula NanoSciences
Product of Encapsula Nanosciences

면책조항

For research use only

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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