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Merck
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Key Documents

937185

Sigma-Aldrich

Polysuccinimide

≥95%, average Mw 60000

동의어(들):

PSI

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About This Item

Linear Formula:
(C4H3NO2)n
CAS Number:
UNSPSC 코드:
12352142
NACRES:
NA.21

Agency

suitable for controlled release

Quality Level

분석

≥95%

형태

powder or chunks

분자량

average Mw 60000

색상

white to light brown

응용 분야

advanced drug delivery
agriculture
cosmetics

일반 설명

Polysuccinimide (PSI), commonly synthesized through thermal polymerization, is a polyimide precursor for the production of such biocompatible and degradable polymers namely polyaspartic acid and various polyaspartamides. Polyaspartic acid is produced by hydrolysis of PSI under alkaline condition while polyaspartamide is produced by ring opening of PSI using a nucleophilic reagent. The presence of amide linkages in these polymers gives them peptide-like structures which is prone to hydrolysis and subsequent degradation. These derivatives could be potential substitutes for different polyamino acids in many medical applications.

애플리케이션

Polysuccinimide (PSI) has been used for a variety of applications including:
  • As a nanocarrier or microcarrier delivery vehicle in pharmaceutical, cosmetic, and agriculture (agrochemical) fields
  • As electrospun fibers, films, meshes or mats for wound healing applications
  • As nanofibers for electronic and biosensor applications
  • As a sustainable and environmentally friendly alternative to non-degradable polymers

특징 및 장점

  • Biodegradable by hydrolysis allowing for sustained and controlled delivery
  • High swelling ratio with superabsorbent properties
  • Water soluble
  • Peptide-like and biocompatible

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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