936553

(S,R,S)-AHPC-acetamido-O-PEG4-C1-acid

≥95%

• 동의어(들): (S)-19-[[(2S,4R)-4-Hydroxy-2-[[4-(4-methylthiazol-5-yl)benzyl]carbamoyl]pyrrolidin-1-yl]carbonyl]-20,20-dimethyl-17-oxo-3,6,9,12,15-pentaoxa-18-azahenicosanoic acid, L-Prolinamide, N-(16-carboxy-1-oxo-3,6,9,12,15-pentaoxahexadec-1-yl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
• 실험식(Hill 표기법): C₃₄H₅₀N₄O₁₁S
• CAS Number: 2172820-13-0
• Molecular Weight: 722.85
• MDL number: MFCD33020897
• UNSPSC 코드: 12352106
• NACRES: NA.22

속성

• ligand: VH032
• Quality Level: 100
• 분석: ≥95%
• 양식: solid (or Chunk(s))
• 색상: off-white to light yellow
• 저장 온도: 2-8°C
• SMILES string: C([C@@H](NC(COCCOCCOCCOCCOCC(O)=O)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1
• InChI: 1S/C34H50N4O11S/c1-23-30(50-22-36-23)25-7-5-24(6-8-25)18-35-32(43)27-17-26(39)19-38(27)33(44)31(34(2,3)4)37-28(40)20-48-15-13-46-11-9-45-10-12-47-14-16-49-21-29(41)42/h5-8,22,26-27,31,39H,9-21H2,1-4H3,(H,35,43)(H,37,40)(H,41,42)/t26-,27+,31-/m1/s1
• InChI key: WLBIKNHFCNHRMV-FMVCKAMOSA-N

설명

애플리케이션

(S,R,S)-AHPC-acetamido-O-PEG4-C1-acid is a functionalized von Hippel-Lindau (VHL) ligand. It contains a terminal carboxyl group for conjugation with amine linkers. A basic building block for development of a protein degrader library.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks

기타 정보

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable