936480

2,7-Diazaspiro[3.5]nonane-7-acetic acid, 2-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-

≥95%

• 동의어(들): 2-(2-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2,7-diazaspiro[3.5]nonan-7-yl)acetic acid, 2-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-2,7-diazaspiro[3.5]nonane-7-acetic acid
• 실험식(Hill 표기법): C₂₂H₂₄N₄O₆
• CAS Number: 2566692-78-0
• Molecular Weight: 440.45
• UNSPSC 코드: 12352106
• NACRES: NA.22

속성

• Quality Level: 100
• 분석: ≥95%
• 양식: powder or crystals
• 색상: Light Yellow to Yellow
• 저장 온도: 2-8°C
• SMILES string: O=C(O)CN1CCC2(CN(C3=CC=C4C(=O)N(C(=O)C4=C3)C5C(=O)NC(=O)CC5)C2)CC1
• InChI key: VCIGJJAMFQFWKB-UHFFFAOYSA-N

설명

애플리케이션

This is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal hydroxyl group. Allows rapid conjugation with many linkers containing active leaving groups. A basic building block for development of a protein degrader library.

Technology Spotlight:

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

기타 정보

Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs

법적 정보

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable