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Merck
모든 사진(1)

주요 문서

935786

Sigma-Aldrich

Shear-thinning gelatin-based photocrosslinkable bioink

suitable for extrusion-based 3D bioprinting

동의어(들):

EASYGEL INX

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About This Item

UNSPSC 코드:
12352201

Quality Level

양식

(transparent gel)

점도

0.1-1 Pa.s (high shear)
200-2500 Pa.s low (shear)

겔 강도

(Storage modulus after UV crosslinking (kPa) 2-6)

일반 설명

The shear-thinning gelatin-based bioink is a extracellular matrix (ECM)- mimicking ink that provides all the benefits of gelatin with the addition of shear thinning behaviour, thereby allowing easy printing at 37°C.

Based on gelatin derived from natural collagen, this bioink has been modified with photocrosslinkable functional groups which enables unpreedneted printing efficiency of a scaffold that resembes the natural ECM and has exptionally high cell viabilities. The shear-thinning gelatin-based bioink combines all the benefits of conventional gelatin or GelMA with the improved printability thanks to its shear thinning behavior. It can be printed at 37°C in the presence or absence of cells, and overcomes the narrow processing range limitations associated with printing conventional GelMA based bioinks. After printing, the material can be photocrosslinked, resunting in a physiologically stable hydrogel.

Processing:
At high shear rates, this bioink exhibits a low viscotiy which allows easy injection from the printing nozzle, At low shear rates, it has a high viscosity, which is required for shape retention after deposition. This is favorable for extrusion-based 3D bioprinters as the ink should easily be injected through the printing nozzle and the post-injetion flow should be minimized to prevent structural deformation. These properties are very rarely seen in conventional gelatin-based ink, giving this bioink an advantage over traditional bioinks.

애플리케이션

Applications: :
3D bioprinting
Tissue engineering
In vitro modeling

특징 및 장점

Features and Benefits:
- Easy printing - Shear thinning behavior enables easy deposition at 37°C
- Biodegradability - Enables cellular remodeling of the printed matrix
- Easy handling - Delivered in a ready-to-use cartridge - UV curable
- Efficient UV-based crosslinking
- Reproducibility - Strict quality control
Cell interactive - Material is biocompatible mimics natural ECM envrionment

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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