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Merck
모든 사진(1)

Key Documents

추가 자료

933651

Sigma-Aldrich

Poly(caprolactone fumarate)

average Mn 5,000

동의어(들):

PCLF, Polycaprolactone fumarate

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모든 사진(1)

About This Item

Linear Formula:
C16H30O7(C20H30O9)n
UNSPSC 코드:
12352207
NACRES:
NA.21

형태

viscous liquid

Quality Level

100

분자량

average Mn 5,000

색상

clear, colorless

저장 온도

−20°C

관련 카테고리

일반 설명

Poly(caprolactone fumarate) (PCLF) is a crosslinkable, biodegradable polymer consisting of poly(caprolactone) (PCL) and unsaturated fumarate repeating units. This derivative of PCL can be crosslinked to form a three-dimensional polymer network or scaffold. PCLF has been widely investigated for tissue engineering, 3D bioprinting, and drug delivery applications due to its biodegradability, biocompatibility and mechanical performance.

애플리케이션

  • Tissue engineering including bone and nerve regeneration
  • 3D bioprinting
  • Drug delivery
Poly(caprolactone fumarate) (PCLF) is a macromonomer consisting of poly(caprolactone) and fumarate repeating units. The bio-compatible poly(capralactone) units shows flexibility and fumarate repeat units provide cross linking ability without adding any toxic cross-linkers

특징 및 장점

  • Biocompatible
  • Crosslinkable via photopolymerization, radical polymerziation, thermal polymereization
  • Flexible polymer chain
  • Biodegradable via hydrolysis of the ster bonds in both PCL and fumarate segments

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

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문서 라이브러리 방문

Synthesis, Material Properties, and Biocompatibility of a Novel Self-Cross-Linkable Poly(caprolactone fumarate) as an Injectable Tissue Engineering Scaffold
Esmaiel J. et al.
Biomacromolecules, 6, 2503-2511 (2005)
Synthesis and manufacture of photocrosslinkable poly(caprolactone)-based three-dimensional scaffolds for tissue engineering applications
N. Castro et al.
Advances in Bioscience and Biotechnology, 2, 167-173 (2011)
M Brett Runge et al.
Acta biomaterialia, 8(1), 133-143 (2011-09-14)
Polycaprolactone fumarate (PCLF) is a cross-linkable derivative of polycaprolactone diol that has been shown to be an effective nerve conduit material that supports regeneration across segmental nerve defects and has warranted future clinical trials. Degradation of PCLF (PCLF(DEG)) releases toxic

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