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Merck
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Key Documents

930741

Sigma-Aldrich

Poly(oligoethylene glycol methacrylate)

동의어(들):

POEGMA, Poly(oligo(ethylene glycol)methacrylate)

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About This Item

Linear Formula:
C6H8NO2[C4H5O2(C2H4O)x]nOH
UNSPSC 코드:
12352104
NACRES:
NA.21

형태

liquid

Quality Level

분자량

80,000-130,000

색상

colorless

저장 온도

−20°C

일반 설명

Poly(oligo(ethylene glycol) methacrylate) (POEGMA) is a family of polymers consisting of a hydrophobic methacrylate backbone and hydrophilic ethylene oxide (EO) side groups with highly branched architecture. The highly branched architecture with a high density of oligo EO moities enhances the solubility of the polymer in water.

애플리케이션

  • Drug delivery- enhances the stability and delivery of siRNA and eliminates PEG antigenicity
  • Biosensor coatings- provides an anti-fouling surface
  • Stimuli-responsive hydrogels for tissue engineering, drug delivery, and other biomedical applications
Poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA) is a family of polymers consisting of a hydrophobic methacrylate backbone and hydrophilic ethylene oxide (EO) side groups with highly branched architecture . The side chain EO segments enhance the solubility of the polymer in water , exhibiting many interesting properties such as non-fouling , stealth, anti-PEG antibodies & thermo-responsive behaviors.

특징 및 장점

  • Highly branched architecture and high density of oligo ethylene oxide moieties
  • Water soluble
  • Nonfouling and thermo-responsive behaviors
  • Viable alternative to PEG in biological and biomaterial applications

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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문서 라이브러리 방문

In Pursuit of Zero 2.0: Recent Developments in Nonfouling Polymer Brushes for Immunoassays
Heggestad J., et al.
Advanced Materials, 32 (2020)
Rafael Pires-Oliveira et al.
Langmuir : the ACS journal of surfaces and colloids, 36(49), 15018-15029 (2020-12-05)
Understanding of the temperature-induced phase transition of poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA) random copolymers with varied composition remains largely incomplete. Upon heating they can form either macroscopically phase-separated aggregates or micelles. We examined the effect of polymer architecture by

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