926248

Redox Responsive Poly(ethylene glycol)-block-poly(lactide-alt-glycolide)

PEG average M_n 5000, PLGA M_n 15000

• 동의어(들): Drug release, PEG-PLGA with disulfide linkage, PEG-SS-PLGA, Stimuli-responsive
• Linear Formula: CH₃O(C₂H₄O)_nC₇H₁₂O₄S₂(C₅H₆O₄)_m
• UNSPSC 코드: 12352112
• NACRES: NA.23

속성

• 형태: powder, chunks or granules
• Quality Level: 100
• 분자량: PEG average M_n 5000; PLGA M_n 15000
• 저장 온도: 2-8°C
• SMILES string: O=C(C(C)OC(CO[H])=O)OCCSSCCOC(OCCOCCOC)=O

설명

애플리케이션

PEG-SS-PLGA is a redox responsive, biocompatible, amphiphilic block copolymer composed of a hydrophilic PEG block and a hydrophobic poly(lactide-alternative-glycolide) (PLGA) block, with a reducible disulfide linkage between blocks. This polymer can be fabricated into Glutathione (GSH) responsive nanoparticles which can be used as an intracellular drug delivery system.

Different from common Poly(lactide-co-glycolide) (PLGA) polymer, the lactic and glycolic units in Poly(lactide-alt-glycolide) block alternate in sequence in the polymer chain, and the molar ratio of lactic to glycolic units in the polymer is exactly 1:1.

Poly(lactide-alt-glycolide) exhibits excellent solubility in common organic solvents, such as acetonitrile, acetone, dioxane, DCM, and THF, providing great convenience for drug delivery researches and applications.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable