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애플리케이션
4-Aminobenzamidine dihydrochloride can be used to synthesize:
- Orally active fibrinogen receptor antagonists based on benzamidines.
- Benzamidine derivatives that are selective and potent serine protease inhibitors.
- Novel pyrrolo [3,2-c] quinolines that are structural analogs of topoisomerase inhibitors such as coralyne and fagaronine.
4-Aminobenzamidine dihydrochloride is used as a ligand in affinity chromatography for purification and immobilization of enzymes.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
이미 열람한 고객
Biochemical and molecular modeling analysis of the ability of two p-aminobenzamidine-based sorbents to selectively purify serine proteases (fibrinogenases) from snake venoms.
De-Simone S G, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 822(1-2), 1-9 (2005)
In vitro blood compatibility of polymeric biomaterials through covalent immobilization of an amidine derivative.
Gouzy M F, et al.
Biomaterials, 25(17), 3493-3501 (2004)
A L Nguyen et al.
Biotechnology and bioengineering, 34(9), 1186-1190 (1989-11-01)
Reactive polymers have been prepared by copolymeriz-ing N-isopropyl acrylamide (NIPAM) with N-acryloxy-succinimide (NASI) or glycidyl methacrylate (GMA). The amino groups of ligands could react with the residues of NASI or GMA and the polymers could be precipitated by temperature and/or
A L Nguyen et al.
Enzyme and microbial technology, 12(9), 663-668 (1990-09-01)
A reactive water-soluble polymer was synthesized by copolymerizing N-isopropylacrylamide and glycidyl acrylate. The reactive polymer could react with the amino groups of enzymes/proteins or other ligands to form an affinity polymer. As a model, the reactive polymer was allowed to
Specific adsorption of serine proteases on coated silica beads substituted with amidine derivatives.
S Khamlichi et al.
Journal of chromatography, 510, 123-132 (1990-06-27)
Amidine derivatives interact with serine proteases, the inhibition being due to interactions between amidine functions and the active sites of the enzymes. Five different types of amidine (substituted or unsubstituted) were coupled to coated silica beads, which had previously been
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