49920

Glycerol formal

≥98.0% (GC)

• 동의어(들): 1,3(or 2,3)-O-Methylene-1,2,3-propanetriol
• 실험식(Hill 표기법): C₄H₈O₃
• CAS Number: 99569-11-6
• Molecular Weight: 104.10
• Beilstein: 103206
• MDL number: MFCD10039829
• UNSPSC 코드: 12352100
• PubChem Substance ID: 57651229
• NACRES: NA.22

속성

• Quality Level: 200
• 분석: ≥98.0% (GC)
• 포함: ~0.02% 2,6-di-tert-butyl-4-methylphenol as stabilizer
• 구성: 5-hydroxy-1,3-dioxane, ~60% ; 4-hydroxymethyl-1,3-dioxolane, ~40%
• refractive index: n20/D 1.451 (lit.); n20/D 1.451
• bp: 192-193 °C (lit.)
• density: 1.203 g/mL at 25 °C (lit.)
• 작용기: ether; hydroxyl
• SMILES string: OCC1COCO1.OC2COCOC2
• InChI: 1S/2C4H8O3/c5-4-1-6-3-7-2-4;5-1-4-2-6-3-7-4/h2*4-5H,1-3H2
• InChI key: JIUMSISXCKWZTA-UHFFFAOYSA-N

설명

일반 설명

Glycerol formal (GF) is a light glycerol acetal that is composed of ~60% 5-hydroxy-1,3-dioxane and ~40% 4-hydroxymethyl-1,3-dioxolane. It can be prepared by reacting glycerol and formaldehyde in the presence of acid catalyst. The potential of GF as an injection solvent for use in toxicity testing has been reported.

애플리케이션

Glycerol formal is used to to solubilize water-insoluble compounds for subsequent aqueous dilution. It has been used as a chemical and dye emulsifier and as a cosolvent for drug delivery. Glycerol formal was used as a vehicle for antibiotic delivery in rats.

Glycerol formal may be used in the multi-step synthesis of 9-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]guanine (2′-nor-2′-deoxyguanosine), an analog of acyclovir. It may be used in the preparation of 4-substituted dioxolanes.

안전성 정보

• WGK: WGK 3
• 개인 보호 장비: Eyeshields, Gloves, type ABEK (EN14387) respirator filter