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Merck
모든 사진(2)

Key Documents

142824

Sigma-Aldrich

1-Methyl-1-cyclohexanecarboxylic acid

99%

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About This Item

Linear Formula:
CH3C6H10CO2H
CAS Number:
Molecular Weight:
142.20
EC Number:
MDL number:
UNSPSC 코드:
12352100
PubChem Substance ID:
NACRES:
NA.22

분석

99%

형태

solid

bp

234 °C (lit.)

mp

36-39 °C (lit.)

작용기

carboxylic acid

SMILES string

CC1(CCCCC1)C(O)=O

InChI

1S/C8H14O2/c1-8(7(9)10)5-3-2-4-6-8/h2-6H2,1H3,(H,9,10)

InChI key

REHQLKUNRPCYEW-UHFFFAOYSA-N

일반 설명

1-Methyl-1-cyclohexanecarboxylic acid is the structural analog of valproic acid and its pharmacokinetic action has been studied in female Sprague-Dawley rats.

애플리케이션

1-Methyl-1-cyclohexanecarboxylic acid was used as internal standard during the determination of valproic acid metabolites.

생화학적/생리학적 작용

1-Methyl-1-cyclohexanecarboxylic acid is an anticonvulsant drug and causes maturation of murine neuroblastoma cells in vitro.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

213.8 °F - closed cup

Flash Point (°C)

101.00 °C - closed cup

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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문서 라이브러리 방문

J C Larcher et al.
Experimental cell research, 203(1), 72-79 (1992-11-01)
Adriamycin, an anticancer agent acting on topoisomerase II, promotes the arrest of cell division and neurite extension in a "neurite-minus" murine neuroblastoma cell line, N1A-103. This morphological differentiation is accompanied by a blockade in the S phase of the cell
J C Larcher et al.
Oncogene, 6(4), 633-638 (1991-04-01)
Using clones N1E-115 and N1A-103 from mouse neuroblastoma C1300, a comparative analysis of c- and N-myc gene expression was undertaken both in proliferating cells and in cultures exposed to conditions which induce differentiation. Under the latter conditions, while N1E-115 cells
A J Sadeque et al.
The Journal of pharmacology and experimental therapeutics, 283(2), 698-703 (1997-11-14)
Cytochrome P450-dependent desaturation of the anticonvulsant drug valproic acid (VPA) results in formation of the hepatotoxin, 4-ene-VPA. Polytherapy with other anticonvulsants which are known P450 inducers increases the flux through this bioactivation pathway. The aim of the present study was
S A Fischkoff et al.
Journal of biological response modifiers, 3(2), 132-137 (1984-01-01)
The anticonvulsant drug 1-methyl-1-cyclohexanecarboxylic acid ( MCCA ) has been shown to cause maturation of murine neuroblastoma cells in vitro at concentrations that are pharmacologically achievable. HL-60 human promyelocytic leukemia cells cultured with this drug underwent a dose-dependent decrease in
J L Vayssiere et al.
Biochemical and biophysical research communications, 140(3), 789-796 (1986-11-14)
CCA, a potent neuroblastoma differentiation inducer, was shown by oxygraphic measurements to reduce significantly the O2 consumption of whole neuroblastoma cells as of mitochondria purified from neuroblastoma or mouse cortex. The effect of CCA on the respiration was compared to

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