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Merck

PDK3

pyruvate dehydrogenase kinase, isozyme 3

동의어:
:
UniProtKB ID:
Clone ID:
  • Human(5165) Summary: The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
  • Mouse(236900) pyruvate dehydrogenase kinase, isoenzyme 3
  • Rat(296849) pyruvate dehydrogenase kinase, isozyme 3
  • chicken(418595) pyruvate dehydrogenase kinase, isozyme 3
  • domestic cat(101095314) pyruvate dehydrogenase kinase, isozyme 3
  • Horse(100060791) pyruvate dehydrogenase kinase, isozyme 3
  • dog(480868) pyruvate dehydrogenase kinase, isozyme 3
  • cow(510841) pyruvate dehydrogenase kinase, isozyme 3
  • sheep(101108725) pyruvate dehydrogenase kinase, isozyme 3
  • naked mole-rat(101699582) pyruvate dehydrogenase kinase, isozyme 3
  • domestic guinea pig(100725367) pyruvate dehydrogenase kinase, isozyme 3

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Antibodies

제품 번호
설명
종별 반응성
응용분야
Anti-PDK3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
종별 반응성
human
응용분야
immunofluorescence
western blot
Anti-PDK3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
종별 반응성
human
응용분야
immunohistochemistry
western blot

Small Molecule - Inhibitor

제품 번호
설명
Sodium dichloroacetate, 98%,
human

Proteins

제품 번호
설명
PDHK3, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
human

esiRNA

제품 번호
설명
MISSION® esiRNA, targeting human PDK3,
human
MISSION® esiRNA, targeting mouse Pdk3,
mouse