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Merck

GRM1

glutamate receptor, metabotropic 1

동의어:
GPRC1A, MGLU1, MGLUR1, SCAR13
종:
UniProtKB ID:
Clone ID:
  • Human(2911) Summary: This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
  • Mouse(14816) glutamate receptor, metabotropic 1
  • Rat(24414) glutamate receptor, metabotropic 1
  • domestic guinea pig(100730891) glutamate receptor, metabotropic 1
  • naked mole-rat(101712477) glutamate receptor, metabotropic 1
  • Domestic Rabbit(100356201) glutamate receptor, metabotropic 1
  • Zebrafish(100150246) glutamate receptor, metabotropic 1
  • dog(484024) glutamate receptor, metabotropic 1
  • domestic cat(101094104) glutamate receptor, metabotropic 1
  • cow(540485) glutamate receptor, metabotropic 1
  • Horse(100060603) glutamate receptor, metabotropic 1
  • chicken(421614) glutamate receptor, metabotropic 1

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Small Molecule - Agonist

제품 번호
설명
(S)-3,5-Dihydroxyphenylglycine hydrate, ≥98% (HPLC), powder,
human
Ibotenic acid, ~95%, solid,
rat
D-2-Aminoadipic acid, ,
rat
L-2-Aminoadipic acid, ≥98% (TLC),
rat, human
Quisqualic acid, powder,
rat

Small Molecule - Antagonist

제품 번호
설명
(+)-α-Methyl-4-carboxyphenylglycine, solid,
rat
SIB 1757, ≥99% (HPLC), crystalline,
human
AIDA, solid,
rat, human
SIB 1893, >99%, solid,
human
D-2-Aminoadipic acid, ,
rat

Antibodies

제품 번호
설명
종별 반응성
응용분야
Anti-Metabotropic Glutamate Receptor 1 Antibody, Chemicon®, from rabbit,
종별 반응성
human
응용분야
immunohistochemistry
Anti-mGluR1 Antibody, Upstate®, from rabbit,
종별 반응성
rat
응용분야
western blot
Monoclonal Anti-Glutamate antibody produced in mouse, clone GLU-4, ascites fluid,
종별 반응성
wide range
응용분야
ELISA
Anti-GRM1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
종별 반응성
human
응용분야
immunohistochemistry
Anti-Metabotropic Glutamate Receptor 1α Antibody, pain, CT, Chemicon®, from rabbit,
종별 반응성
human, monkey, rat
응용분야
immunohistochemistry
western blot

Small Molecule - Inhibitor

제품 번호
설명
L-2-Aminoadipic acid, ≥98% (TLC),
rat, human
Quisqualic acid, powder,
rat
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
rat, human
(Aminomethyl)phosphonic acid, 99%,
rat, human
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
rat, human

Small Molecule - Mixed Agonist/Antagonist

제품 번호
설명
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
rat, human
(±)-AMPA, solid,
rat
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
rat, human
L-Glutamic acid, BioUltra, ≥99.5% (NT),
rat, human
L-Glutamic acid, FCC,
rat, human

esiRNA

제품 번호
설명
MISSION® esiRNA, targeting human GRM1,
human
MISSION® esiRNA, targeting mouse Grm1,
mouse