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Merck

ERBB2

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2

동의어:
CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
:
UniProtKB ID:
Clone ID:
  • Human(2064) Summary: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
  • Mouse(13866) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • Rat(24337) v-erb-b2 avian erythroblastic leukemia viral oncogene 2
  • sheep(780519) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • Domestic Rabbit(100009554) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • naked mole-rat(101705227) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • domestic guinea pig(100727657) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • Zebrafish(386966) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
  • cow(505709) v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
  • Horse(100054739) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • domestic cat(751824) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • dog(403883) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • chicken(426130) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

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ELISA

제품 번호
설명
Phosphotyrosine ERBB2 / Receptor Tyrosine-protein Kinase erbB-2 ELISA Kit, ,
human

Antibodies

제품 번호
설명
종별 반응성
응용분야
Monoclonal Anti-c-erbB-2 antibody produced in mouse, ~2 mg/mL, clone HER2-96, purified immunoglobulin, buffered aqueous solution,
종별 반응성
human
응용분야
ELISA
immunoprecipitation (IP)

microarray
Anti-HER2 antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, mouse, rat
응용분야
ELISA
immunofluorescence
Anti-HER2 antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, mouse, rat
응용분야
ELISA
immunohistochemistry

western blot
Anti-HER2 antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, mouse, rat
응용분야
ELISA
immunohistochemistry

western blot
Anti-ERBB2 antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
종별 반응성
human
응용분야
immunofluorescence
immunohistochemistry

western blot

Cell Lines

제품 번호
설명
MCF10A CELLS HER2 (-/-) EXON 2, ,
human
SKOV3 Cells GFP-HER2, ,
human
SKOV3 Cells GFP-HER2 RFP-EGFR, ,
human

Small Molecule - Inhibitor

제품 번호
설명
Mubritinib, ≥98% (HPLC),
human
CP724714, ≥98% (HPLC),
human
Tyrphostin AG 879, 99% (HPLC),
human
Lapatinib, ,
human
Lapatinib, ≥98% (HPLC),
human

Proteins

제품 번호
설명
HER2 (676-end), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
human

esiRNA

제품 번호
설명
MISSION® esiRNA, targeting human ERBB2,
human
MISSION® esiRNA, targeting mouse Erbb2,
mouse