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Merck

CYP3A4

cytochrome P450, family 3, subfamily A, polypeptide 4

동의어:
CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1
:
UniProtKB ID:
Clone ID:
  • Human(1576) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011]
  • chicken(416477) cytochrome P450, family 3, subfamily A, polypeptide 4
  • Horse(100294525) cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
  • dog(479740) cytochrome P450, family 3, subfamily A, polypeptide 4
  • cow(507988) cytochrome P450, subfamily IIIA, polypeptide 4

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Antibodies

제품 번호
설명
종별 반응성
응용분야
Anti-CYP3A4 antibody produced in mouse, IgG fraction of antiserum, buffered aqueous solution,
종별 반응성
human
응용분야
immunohistochemistry
western blot
Anti-Cytochrome P450 Enzyme CYP3A4 Antibody, serum, Chemicon®,
종별 반응성
human, mammals, pig, rat
응용분야
immunohistochemistry
western blot
Anti-CYP3A4 antibody produced in rabbit, ,
종별 반응성
human, mouse, rat
응용분야
immunofluorescence
immunohistochemistry

western blot
Monoclonal Anti-CYP3A4 antibody produced in mouse, clone 3H8, purified immunoglobulin, buffered aqueous solution,
종별 반응성
human
응용분야
ELISA
flow cytometry

immunofluorescence

immunohistochemistry

western blot

Small Molecule - Inhibitor

제품 번호
설명
Piperine, ≥95%, FG,
human
Piperine, ≥97%,
human
Ivermectin, ,
mouse, human
Clotrimazole, ,
mouse, human
Erythromycin, tested according to Ph. Eur.,
mouse, human

Proteins

제품 번호
설명
Cytochrome P450 3A4 human, recombinant, expressed in E. coli,
human
CypExpress 3A4 Cytochrome P450 human, ,
human

esiRNA

제품 번호
설명
MISSION® esiRNA, targeting human CYP3A4,
human