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G005522

HPLC Analysis of Oxprenolol Enantiomers on Astec® Cellulose DMP

application for HPLC

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technique(s)

HPLC: suitable

test parameters

column: Astec Cellulose DMP, 25 cm x 4.6 mm I.D., 5 μm particles (51099AST)
mobile phase: [A] heptane; [B] isopropanol; [C] diethylamine; (80:20:0.1, A:B:C)
flow rate: 1 mL/min
column temp.: 30 °C
detector: UV, 254 nm
injection: 15 μL
sample: oxprenolol, 1 g/L in 50:50 heptane:isopropanol

suitability

application for HPLC

application(s)

pharmaceutical (small molecule)

Analysis Note

Oxprenolol enantiomers are resolved by normal phase chromatography.

Other Notes

Oxprenolol is a nonselective beta-blocker and is used to treat angina and hypertension.

Legal Information

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany

analytical column

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