Skip to Content
Merck
All Photos(1)

Key Documents

More Documents

SML1213

Sigma-Aldrich

A66

≥98% (HPLC)

Synonym(s):

(2S)-N1-[2-(1,1-Dimethylethyl)-4′-methyl[4,5′-bithiazol]-2′-yl]-1,2-pyrrolidinedicarboxamide

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C17H23N5O2S2
CAS Number:
1166227-08-2
Molecular Weight:
393.53
MDL number:
MFCD22378485
UNSPSC Code:
12352200
PubChem Substance ID:
329825723
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C(N1[C@H](C(N)=O)CCC1)NC2=NC(C)=C(C3=CSC(C(C)(C)C)=N3)S2

InChI

1S/C17H23N5O2S2/c1-9-12(10-8-25-14(20-10)17(2,3)4)26-15(19-9)21-16(24)22-7-5-6-11(22)13(18)23/h8,11H,5-7H2,1-4H3,(H2,18,23)(H,19,21,24)/t11-/m0/s1

InChI key

HBPXWEPKNBHKAX-NSHDSACASA-N

Biochem/physiol Actions

A66 is a potent and highly selective inhibitor of the phosphoinositide 3-kinase (PI3K) catalytic subunit p110α with an IC50 of 32 nM and >100 fold selectivity for p110α over other class-I PI3K isoforms.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Hector J Monzo et al.
Experimental cell research, 355(1), 26-39 (2017-03-28)
Cellular interactions with the extracellular environment are modulated by cell surface polysialic acid (PSA) carried by the neural cell adhesion molecule (NCAM). PSA-NCAM is involved in cellular processes such as differentiation, plasticity, and migration, and is elevated in Alzheimer's disease

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service