SML0584

NNGH

≥98% (HPLC)

• Synonym(s): BML-205, N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid
• Empirical Formula (Hill Notation): C₁₃H₂₀N₂O₅S
• CAS Number: 161314-17-6
• Molecular Weight: 316.37
• MDL number: MFCD02179370
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825565

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 15 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: COc1ccc(cc1)S(=O)(=O)N(CC(C)C)CC(=O)NO
• InChI: 1S/C13H20N2O5S/c1-10(2)8-15(9-13(16)14-17)21(18,19)12-6-4-11(20-3)5-7-12/h4-7,10,17H,8-9H2,1-3H3,(H,14,16)
• InChI key: JIRXORZYIXSWOB-UHFFFAOYSA-N

Description

Biochem/physiol Actions

NNGH is a potent and cell-permeable inhibitor of matrix metalloproteinase 3 (MMP-3,stromelysin 1, progelatinase). NNGH has been used to inhibit MMP-3 in a variety of studies. Inhibition of MMP-3 with NNGH significantly suppressed the expression of iNOS and pro-inflammatory cytokines and the activities of NF-KB, AP-1, and MAPK in LPS-stimulated microglia, suggesting a role for MMP-3 in neuroinflammation.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable